Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Jarry, Hubertus Prof. Dr."
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Preclinical evaluation of nanoparticle enhanced breast cancer diagnosis and radiation therapy
(2021-07-09)Triple negative breast cancer (TNBC) is an aggressive type of cancer which makes up 15-20% of all newly diagnosed cases, lacking the main target molecules for tumor specific treatment. Surgery or systemic therapy by ... -
NFATc1 driven ER-stress responses in the progression of non-alcoholic fatty liver disease
(2021-06-30)Non-alcoholic fatty liver disease (NAFLD) mirrors the hepatic manifestation of the metabolic syndrome and is defined by progressive fat accumulation in hepatocytes (steatosis). Uncomplicated NAFLD may progress to a severe ... -
The role of Hedgehog signalling in pituitary homeostasis in vitro and in vivo
(2020-11-03)The pivotal role of the Hedgehog (Hh) signalling pathway during embryonal development of the pituitary gland is well established. However, the knowledge about its function in the adult pituitary is still sparse. Our group ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
Modulation of allergic airway inflammation by glucocorticoids
(2014-03-06)A crucial step in the development of improved drugs for asthma therapy is a thorough understanding of the mechanisms, which are important for effective treatment, and the identification of target cells in asthma pathogenesis. ... -
Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat
(2011-04-21)Stress facilitates the development of psychiatric disorders in vulnerable individuals. Previous studies have well documented the impact of stress on glutamatergic excitatory transmission ...