Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Klopfenstein, Dieter Dr."
Now showing items 1-11 of 11
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Actin promotes chromosome aggregation and accurate chromosome segregation in mammalian oocytes
(2022-09-15)Accurate chromosome segregation during meiosis is essential for the formation of a new life. During meiosis, spindle microtubules bind to the chromosomes’ kinetochores and arms in order to separate the genetic material. ... -
Mechanisms of pronuclear migration in mammalian zygotes
(2019-08-30)In sexually reproducing species, life begins with the fusion of egg and sperm to form the one-cell embryo, called the zygote. Maternal and paternal DNA form the female and male pronuclei, and must migrate to each other to ... -
Study of a kinesin adaptor in axonal transport and synapse formation
(2019-02-25)To form a synaptic terminal, various components have to be targeted to specific sites in the axon. Presynaptic proteins are synthesized in the cell soma, packaged in vesicular cargos and transported by the motor complexes ... -
The Principles of Self-Organization of Memories in Neural Networks for Generating and Performing Cognitive Strategies
(2018-12-12)Higher-order animals exhibit the remarkable ability to dynamically adapt to a changing environment. On the neuronal level, they have to form mental representations of specific stimuli, so-called memories. Furthermore, ... -
Identifying stage-specific markers of Alzheimer's disease using quantitative proteomics
(2018-09-13)Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that leads to progressive memory loss and impairment of other cognitive functions. It is the most prevalent form of dementia in the elderly and is estimated ... -
Novel export and import pathways in S. cerevisiae identified by an engineered SUMO system
(2018-09-07)Nuclear transport receptors (NTRs) mediate the translocation of cargos between the cytoplasm and the nucleus. NTRs are classified either as importins or exportins according to the directionality of the cargo transport. To ... -
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
Molecular mechanisms of collybistin-dependent gephyrin clustering at inhibitory synapses
(2014-07-03)Information processing and transmission in neuronal networks in the mammalian brain occurs through intercellular communication between neurons at synapses. Inhibitory synapses play a key role, for example to maintain network ... -
Development of Fluorescence Activated Synaptosome Sorting (FASS) and analysis of VGLUT1 synapses from mouse brain
(2012-10-05)Signal propagation between neurons in the brain is mediated by chemical synapses. Depending on the neurotransmitters and their receptors, synapses can transmit excitatory, inhibitory, or modulatory signals. A detailed ... -
Neuroligin 2 Induced Allosteric Transition of Collybistin Underlies Inhibitory Postsynaptic Differentiation
(2011-06-03)Synaptic inhibition is vital to brain function. GABAergic and glycinergic synapses, mediating fast inhibition in the mammalian central nervous system (CNS), balance the activity of neural circuits. At the inhibitory ... -
Regulation of recycling endosomal membrane traffic by a γ-BAR/ kinesin KIF5 complex
(2008-01-15)Intracellular trafficking of membrane proteins and lipids between different compartments is a fundamental process underlying a variety of cell physiological functions of eukaryotic cells. ...