Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Konrad, Manfred Dr."
Now showing items 1-4 of 4
-
Maintenance of glutamate homeostasis in Bacillus subtilis by complex regulatory systems and genomic adaptation
(2017-10-16)The Gram-positive model organism Bacillus subtilis lives in the soil and must cope with a constantly changing environment. Glutamate plays an important role in cellular metabolism, because it is the major amino group ... -
Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs
(2015-07-28)Deoxyribonucleoside and nucleotide kinases are key enzymes that catalyze the critical phosphorylation steps in the conversion of antiviral and anticancer nucleoside analogs to their corresponding cytotoxic nucleoside ... -
Dynamic interactions during ribosome targeting to the membrane
(2015-05-11)The signal recognition particle (SRP) and its receptor are the main components of the co-translational protein targeting pathway by which membrane proteins are targeted to the membrane. The co-translational targeting pathway ... -
Biochemical Characterization and Engineering of L-asparaginases for Amino Acid Depletion Therapy of Acute Lymphoblastic Leukemia
(2014-06-25)The goal of the present work was to form a basis for the development of improved protein therapeutics against acute lymphoblastic leukemia (ALL). Bacterial L-asparaginases, in combination with other chemotherapeutics, are ...