Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Kramer, Wilfried PD Dr."
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Analysis of Mdm38 function in mitochondrial translation
(2015-11-05)The data presented in this thesis demonstrate that binding of Mdm38 to ribosomes has conserved characteristics in yeast and E. coli. To gain further insights into potential binding partners, an in vivo photo cross-linking ... -
Characterization of mRNA export and nuclear quality control under heat stress in the yeast Saccharomyces cerevisiae
(2017-05-17)Elevated temperatures and other changes of the environment a cell lives in, can have tremendous impact on cellular processes and integrity. To counteract these threats, cells have established various mechanisms to avoid ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Role of 5-FU in DNA double strand break repair for improved targets in colorectal cancer therapy
(2015-04-14)Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the world, and 5-Fluorouracil (5-FU) based regimens are chiefly employed for its therapy. Modern regimens, based on 5-FU in combination with ... -
The phosphatase MKP1 as a target to enhance replicative stress and apoptosis in tumor cells
(2016-04-29)DNA replication is a tightly regulated elementary process that ensures the exact duplication and transfer of genetic information to the next generation. However, a wide range of exogenous and endogenous genotoxic insults ...