Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Kube, Dieter Prof. Dr."
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A crosstalk between NF-κB and STAT1 signal transduction pathways in ischemic and proliferative diseases
(2024-07-08)The cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) executes anti-microbial and pro-apoptotic functions, while loss-offunction mutations in the STAT1 gene are associated with ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Role of BRD4 and histone acetylation in estrogen receptor-positive breast cancers
(2015-09-10)The estrogen receptor-α (ERα) acts as a nuclear transcription factor to promote estrogen-induced transcription and plays a central role in the progression of ER-positive tumors. ERα binds to the consensus DNA elements ... -
Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors
(2015-04-15)Pancreatic tumor is one of the leading causes of cancer-related deaths in the world. Currently, the nucleoside analogue gemcitabine is the leading therapeutic drug for the treatment of pancreatic tumors. However, due to ... -
The role and regulation of histone H2B monoubiquitination during tumorigenesis
(2014-05-23)Posttranslational histone modifications are recognized as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), has diverse functions and is involved in gene ...