Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Lehnart, Stephan E. Prof. Dr."
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Phospholamban – Characterization of the Potential Interaction Partner SLMAP
(2024-10-10)The identification of novel PLN interaction partners is of high importance to understand how it is regulated on a molecular level and to develop new therapeutic strategies for cardiomyopathy. SLMAP, a novel putative PLN ... -
Development of mass spectrometry-based proteome analysis workflows for the systematic study of cardiac disease research models
(2024-09-26)A specific variant of genetic mutation in the phospholamban gene expresses a cardiac phospholamban protein lacking the arginine amino acid at position 14 (R14Δ-PLN). The mutation is believed to have a founder in the ... -
Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
(2024-06-18)A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal ... -
Proximity and Affinity based Analysis of Cardiac Caveolin Protein Interactions
(2020-03-06)Background and Objectives: The Caveolin (CAV1-3) family contains a unique class of membrane integral proteins with cytosolic termini. CAV1 or CAV3 are essential components of the caveolar core complex, a disc-shaped ...