Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Liepe, Juliane Dr."
Now showing items 1-7 of 7
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Computational methods for prokaryotic (meta)genomic annotation and function prediction using horizontal information transfer
(2024-08-05)In recent decades, there has been a surge in genomic sequences resulting from large-scale genomic and metagenomic sequencing projects, driven by the significant drop in sequencing costs. More powerful methods to annotate ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Absolute quantification of peptide products in in vitro digestions: A computational approach using Bayesian inference
(2023-06-29)Insight into enzyme specificities and dynamics is central to understanding biochemical processes. The peptide products generated by purified proteases in in vitro digestions are often identified by mass spectrometry ... -
The role of proteasome generated spliced peptides in the adaptive immune response
(2022-05-20)CD8+ T-cells are the crucial component of the adaptive immune system as they survey the cells of the body for the signs of pathogens or tumours and eliminate them when necessary. To do this, T-cells recognise short antigenic ... -
Bioinformatics analysis of multi-omics data elucidates U2 snRNP function in transcription
(2021-08-16)Transcription by RNA polymerase II (Pol II) is an important step in cell function and regulation. Pol II transcription has been shown to be coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly ... -
Structure-based mechanistic analysis of the proteasome
(2019-05-02)The ubiquitin proteasome pathway is one of the major protein degradation pathways in the cell. This pathway is essential for protein quality control and the regulation of the cell cycle. Proteins subjected to the ubiquitin ... -
High-resolution structure determination of human spliceosome complexes by cryo-EM
(2019-02-14)The eukaryotic splicing of precursors to mRNA is facilitated by a highly dynamic, multi-megadalton macromolecular machine termed the spliceosome. The underlying chemical reaction features the excision of an intron, which ...