Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Meinecke, Michael Prof. Dr."
Now showing items 1-17 of 17
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Investigation of the fusion machinery reconstituted into novel pore-spanning membranes
(2024-09-06)The release of neurotransmitter into the synaptic cleft is achieved by fusion of synaptic vesicles with the presynaptic membrane. This essential process in the neuronal signal transmission is driven by the soluble ... -
Giant plasma membrane vesicle-derived in vitro systems to study the structure and dynamics of CaV1.3 channel clusters
(2023-11-06)The voltage-gated calcium channel 1.3 (CaV1.3) has plentiful tasks in the human body. One of them is the excitation-contraction coupling within the heart, where it is known to form CaV1.3 channel cluster. However, their ... -
Molecular characterization of protein-dependent lipid transport during mitochondrial biogenesis
(2022-05-18)Mitochondria are comprised of two membranes, each with a unique lipid and protein composition, subdividing this organelle into the outer mitochondrial membrane (OMM), the intermembrane space (IMS), the inner mitochondrial ... -
Decoding and influencing mitochondrial inner membrane ultra-structure biogenesis
(2022-04-28)The Mitochondrion is a ubiquitous organelle known to be involved in a variety of vital cellular functions besides its central role in ATP synthesis such as, cellular metabolism, signalling and apoptosis. Dynamic in both ... -
Intermediate filament mechanics across scales
(2022-02-24)The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of ... -
Molecular insights into the roles of RNA helicases during large ribosomal subunit assembly
(2021-02-25)RNA helicases are enzymes present in all domains of life that are important in many aspects of RNA metabolism. They harbor a conserved helicase core that uses the energy of NTP binding and hydrolysis to change affinity to ... -
Insights into the biogenesis of the human mitochondrial ribosomal large subunit – Characterisation of mL44 and mL45
(2020-11-16)Due to the presence of high-resolution cryo-EM structures of the human mitoribosome, the understanding about the function and assembly of the intriguing mitochondrial ribonucleoprotein complex increased tremendously during ... -
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
(2020-05-29)RNA helicases are a highly conserved family of proteins that act as RNA-dependent NTPases. These proteins contain a conserved helicase core consisting of two RecA-like domains that are responsible for unwinding or annealing ... -
Reconstitution of retrotranslocation by the Hrd1 ubiquitin ligase with purified components
(2020-03-11)In eukaryotic organisms, a large fraction of newly-synthesized proteins are destined for the endomembrane system or for secretion. The entry gate for these proteins is the endoplasmic reticulum (ER). Proteins are imported ... -
Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Functional analyses of RNA helicases in human ribosome biogenesis
(2019-10-30)Eukaryotic ribosomes are essential ribonucleoprotein (RNP) complexes consisting of four ribosomal RNAs (18S, 5S, 5.8S, 28S/25S) and approximately 80 ribosomal proteins, which are required for the process of translating the ... -
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ... -
Analysis of Protein Transport to the Inner Nuclear Membrane
(2019-07-10)The eukaryotic cell is divided into different compartments. The biggest compartment is the nucleus which is formed by one lipid bilayer folded into two membranes: the outer nuclear membrane (ONM) and the inner nuclear ... -
The role of mammalian TRC40 in membrane-protein targeting and chaperoning
(2019-05-24)Tail-anchored (TA) proteins are distinguished from other membrane proteins due to their particular topology. The best-characterized pathway for the targeting of TA-proteins is the GET pathway in yeast or the TRC pathway ... -
Cortical Tension of Cells: From Apical Membrane Patches to Patterned Cells
(2018-12-05)During their lifetime, cells and tissues have to deal with a variety of mechanical challenges. Shear forces exist inside of vessels, bones have to carry the weight of organisms and connective tissues are generally deformed ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Role of WRB protein in cardiac function
(2017-08-24)The mammalian TRC40 system is a conserved pathway responsible for the post-translational targeting of tail-anchored proteins, which are characterized by a single transmembrane domain at the C-terminus and an N-terminus ...