Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Melchior, Frauke Prof. Dr."
Now showing items 1-9 of 9
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Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells
(2011-09-15)Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and ... -
Functional and mechanistic characterization of the F-box protein Fbxw5
(2011-08-09)Targeted protein ubiquitylation that occurs in eukaroytes is often performed by cullin-RING-based E3 Ubiquitin ligases (CRLs), a superfamily of E3s. These types of ligases are composed of ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
Mechanisms of the intracellular localization of the SUMO-activating enzyme Aos1/Uba2
(2010-06-16)Dynamic posttranslational modification with ubiquitin related proteins of the SUMO (small ubiquitin-related modifier) family is an important cellular mechanism to alter the activity, abundance ... -
SUMOylation modulates α-synuclein toxicity and fibril formation
(2010-01-18)SUMOylation is a highly dynamic posttranslational modification in which covalent attachment of the small ubiquitin-like modifier protein (SUMO) is modulating different substrate specific ... -
Self-association of adenovirus 5 E1B-55 kDa as well as p53 is essential for their mutual interaction
(2009-12-15)P53 is at the center of the control systems that mediate the response to DNA damage, leading to cell cycle arrest or apoptosis. Virus infection can cause a DNA damage response through virus ... -
Combining induced protease fragment assembly and microarray analysis to monitor signaling in living cells.
(2009-11-19)The ability to monitor multiple signaling events simultaneously in living cells is essential to better understand complex biological processes. So far, DNA-microarray technologies provide ... -
Characterization of the Munc13 - CaM Interaction
(2009-07-06)The Munc13 proteins are the key mediators of synaptic vesicle priming, an essential step in Ca2+-regulated neurotransmitter release that renders docked vesicles fusion-competent prior to ... -
"Eine neue Rolle für Myelin-assoziierte Inhibitoren für die Mobilität von Mikroglia"
(2009-05-28)In the central nervous system of mammals, the regeneration of axons after injury is limited. The reduced ability of neurite outgrowth can be attributed, in part, to the presence of inhibitor proteins enriched in myelin. ...