Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Meyer, Thomas Prof. Dr."
Now showing items 1-6 of 6
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The role of STAT1 signal transduction in the pathogenesis of Alzheimer’s disease
(2025-11-06)Chronic neuroinflammation is considered a key hallmark of Alzheimer’s disease (AD) and may represent a central mechanism in its pathogenesis. Microglia, the resident immune cells of the central nervous system (CNS), are ... -
Deciphering novel pathomechanisms initiating and maintaining atrial fibrillation
(2025-06-17)Atrial fibrillation (AF) is the most common arrhythmia and AF burden is projected to rise in the next years. This may be partially attributed to limited efficacy of current antiarrhythmic therapies and interventions. A ... -
Deep Myocardial Phenotyping of the Noonan Syndrome-causing Mutation RIT1<sup>F82L/+</sup> In Vitro and RAS/MAPK Signalling as a Therapeutic Target
(2024-10-23)Noonan syndrome (NS) belongs to the RASopathies, which describe a group of rare developmental disorders caused by heterozygous germline mutations leading to a dysregulation of the Ras/mitogen-activated protein kinase ... -
A pilot study assessing neurophysiological and cardiovascular effects of non-invasive vagus nerve stimulation in healthy subjects and patients with restless legs syndrome
(2023-08-31)Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is an auspicious neurostimulation technique intensively investigated for its potential antidepressant, anticonvulsive, anti-inflammatory and analgesic ... -
Strain-specific profiling of Amyloid-β in Alzheimer´s disease: functional and clinical signature
(2020-05-29)The molecular culprits driving the atypical clinical variants of Alzheimer’s disease (AD), including the recently discovered rapidly progressive AD (rpAD), are unknown to date. Of the several mechanisms being studied in ... -
The role of alpha-synuclein on transcriptional deregulation in Parkinson’s disease
(2018-08-31)Parkinson’s disease (PD) is a complex neurodegenerative disorder that manifests through a broad ran ge of motor and non - motor symptoms. Alpha - synuclein (aSyn) is the major ...