Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Morgenstern, Burkhard Prof. Dr."
Now showing items 1-13 of 13
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Computational methods for prokaryotic (meta)genomic annotation and function prediction using horizontal information transfer
(2024-08-05)In recent decades, there has been a surge in genomic sequences resulting from large-scale genomic and metagenomic sequencing projects, driven by the significant drop in sequencing costs. More powerful methods to annotate ... -
From annotation to bacterial data models
(2022-06-24)Science and technological advancements walk side-by-side and with the recent emergence of novel high throughput techniques, the necessity to have specialized data structures to host and represent the complex and high variety ... -
Discovery and prediction of protein binding sites in DNA and RNA sequences using Bayesian Markov models
(2021-04-23)Transcription factors control the essential step of gene expression via recognizing the over- represented binding sites (or motifs) on the genome. One crucial task is to accurately predict these binding sites on the ... -
Clostridioides difficile: Analysis on Single Cell Motility and on Antibiotic Resistance
(2020-12-22)Clostridioides difficile, formerly in the genus Clostridium, is a Gram positive obligatory anaerobic spore forming bacterium. C. difficile is the leading nosocomial gastrointestinal pathogen in the western world. In ... -
SubtiWiki 3.0: A relational database for the functional genome annotation of the model organism Bacillus subtilis
(2018-02-12)Biological databases emerged in the 1970s along with the rapid development of information science. Since then, they have greatly helped the research community in data management and information sharing, especially the model ... -
Pathway and network analyses in context of Wnt signaling in breast cancer
(2016-03-01)A complex network of interplaying signaling pathways governs cell behavior and phenotype. Wnt signaling pathways are part of this network and play an important role in embryonic development as well as in carcinogenesis. ... -
Statistical models for large-scale comparative metagenome analysis
(2015-04-22)Metagenomics, as a culture-independent approach, enables the exploration of complex heterogeneous microbial communities under natural conditions by massive sequencing of community-specific DNA. Metagenomic data sets, derived ... -
Gene Ontology-based framework to annotate genes of hearing
(2013-10-22)As the number of discovered deafness genes and our knowledge about their role in hearing continuously increases, the need to accurately manage this genetic information is becoming more apparent. Gene Ontology (GO) is a ... -
Genome-wide analysis of mutually exclusive splicing
(2013-02-14)In recent years, advances in sequencing techniques resulted in an explosive increase in sequencing data. Here, computational methods and bioinformatical analyses are presented that provide approaches to keep pace with the ... -
Genomics and Phylogeny of Cytoskeletal Proteins: Tools and Analyses
(2013-02-05)Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein: Background Dynactin is a large multisubunit protein complex that enhances the processivity of cytoplasmic dynein and acts as an adapter ... -
Kristallographische Untersuchungen zur Schweren Kette von Dynein und dem Capping-Protein Cap32/34
(2012-03-16)Intracellular movements are an essential prerequisite for material transport, cell division and food ingestion. They can be mediated through two different ways. Firstly, through motor ... -
Systems biology in Bacillus subtilis
(2010-11-16)Systems biology studies the way in which interaction of different types of molecules results in complex behaviour at the cellular, organism, and higher levels. It approaches these questions ... -
Phylogenetic studies of the vesicular fusion machinery
(2010-10-01)The eukaryotic cell consists of a large system of membrane delimited compartments. Material exchange between these compartments is mediated by intracellular trafficking vesicles. These ...