Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Papantonis, Argyris Prof. Dr."
Now showing items 1-10 of 10
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Dependency of 3D chromatin folding on RNA polymerase II at different cell cycle stages
(2023-07-13)In human cells, the genetic information is organised in a multilayer fashion. During the cell cycle, chromatin undergoes dramatic structural changes. For proper inheritance, chromatin is compacted to chromosomes in ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Gene expression divergence during Drosophila head development on single nuclei resolution
(2023-11-01)In this work, I optimized single-nuclei and single-cell RNA sequencing protocols for working with small amounts of input tissue. Using one of these protocols, I generated 14 single-nuclei RNA expression datasets. These ... -
Investigating phase separation mechanisms for transcriptional control
(2020-11-13)Transcription of protein-coding genes by RNA polymerase (Pol) II is a highly coordinated process. In metazoan cells, transcription is regulated both at the initiation step by recruitment of the Pol II machinery as well as ... -
Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning
(2024-07-09)Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ... -
Non-canonical functions of the MDM2 oncoprotein
(2022-11-04)The tumour suppressor gene TP53 is mutated in ~50% of human cancers. The p53 protein is a transcription factor which is induced by several cellular stresses, such as ribosomal stress and DNA damage. Expression of its target ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Unraveling the Role of TET3 in regulating EndMT in Cardiac Fibrosis
(2023-02-10)DNA methylation and subsequent silencing of gene expression is associated with disease states including tumorigenesis and fibrosis. Although DNA methylation is a dynamic and reversible process, the mechanisms of and ...