Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Papantonis, Argyris Prof. Dr."
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Dependency of 3D chromatin folding on RNA polymerase II at different cell cycle stages
(2023-07-13)In human cells, the genetic information is organised in a multilayer fashion. During the cell cycle, chromatin undergoes dramatic structural changes. For proper inheritance, chromatin is compacted to chromosomes in ... -
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
Gene expression divergence during Drosophila head development on single nuclei resolution
(2023-11-01)In this work, I optimized single-nuclei and single-cell RNA sequencing protocols for working with small amounts of input tissue. Using one of these protocols, I generated 14 single-nuclei RNA expression datasets. These ... -
Investigating phase separation mechanisms for transcriptional control
(2020-11-13)Transcription of protein-coding genes by RNA polymerase (Pol) II is a highly coordinated process. In metazoan cells, transcription is regulated both at the initiation step by recruitment of the Pol II machinery as well as ... -
Non-canonical functions of the MDM2 oncoprotein
(2022-11-04)The tumour suppressor gene TP53 is mutated in ~50% of human cancers. The p53 protein is a transcription factor which is induced by several cellular stresses, such as ribosomal stress and DNA damage. Expression of its target ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Unraveling the Role of TET3 in regulating EndMT in Cardiac Fibrosis
(2023-02-10)DNA methylation and subsequent silencing of gene expression is associated with disease states including tumorigenesis and fibrosis. Although DNA methylation is a dynamic and reversible process, the mechanisms of and ...