Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Pardo, Luis A. Dr."
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The implication of Kv10.1 in the regulation of G2/M progression
(2020-05-19)Kv10.1, also termed Eag1 (Ether-a-go-go1), is a voltage gated potassium channel, initially thought to be expressed in the central nervous system. Prolonged or increased expression of Kv10.1 has been found in over 70% of ... -
Mover affects a subpool of primed synaptic vesicles in the mouse calyx of Held
(2019-10-10)Neuronal communication is a complex process; synapses must be formed, neurotransmitter has to be released at precise time points and it has to be “sensed” by the receiving end of a synapse with an equal accuracy. In this ... -
Touching upon regulators of Piezo2 in mouse somatosensation
(2018-03-15)ABSTRACT Mechanosensation is an integral property of sensory systems like audition and somatosensation. The molecular determinants of mechanotransduction in mammals are only beginning to be understood. In 2010, Piezo2, a ... -
Voltage-gating and assembly of split Kv10.1 channels
(2016-07-04)Voltage-gated ion channels allow ions to pass cell membrane upon changes of transmembrane electrical potential. Conformational changes in the voltage-sensing domain of the channel (VSD) are assumed to be transmitted to the ... -
Role of alternative splicing in the biological properties of the voltage-gated potassium channel Kv10.1
(2014-06-02)In the past few years, several publications highlighted the role of alternative splicing as additional source of modulation of ion channels activity. E65 and E70 (also termed as KV10.1Δ4-7 and KV10.1Δ4-9) represent two ...