Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Posnien, Nico Dr."
Now showing items 1-8 of 8
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Conservation and divergence of the retinal homeobox genetic neural lineage between Drosophila melanogaster and Tribolium castaneum
(2024-06-25)Brains are the central organ integrating sensory information and orchestrating behaviour. Their function and development are of great scientific interest, but their enormous complexity makes them difficult to study. The ... -
Gene expression divergence during Drosophila head development on single nuclei resolution
(2023-11-01)In this work, I optimized single-nuclei and single-cell RNA sequencing protocols for working with small amounts of input tissue. Using one of these protocols, I generated 14 single-nuclei RNA expression datasets. These ... -
Identification of a novel subnetwork involved in eye size variation between Drosophila melanogaster and D. mauritiana
(2022-04-07)The Mendelian genetics concept relies on simple genotype-phenotype relationships with few genes having major effects on the phenotype. However, many traits evolve by a combination of variation in many genomic loci with ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
The role of Hedgehog signalling in pituitary homeostasis in vitro and in vivo
(2020-11-03)The pivotal role of the Hedgehog (Hh) signalling pathway during embryonal development of the pituitary gland is well established. However, the knowledge about its function in the adult pituitary is still sparse. Our group ... -
Investigating the Re-initiation of Segmentation with Temporally Restricted RNAi in Tribolium castaneum
(2020-10-01)Much of the success of arthropods is attributed to their body’s segmentation. Segmentation provides various opportunities for nature to evolve new structures without greatly impacting overall fitness of the animal. Most ... -
Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ... -
Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
(2016-09-09)The great diversity of adult morphologies that we can observe in nature is the product of millions of years of evolution of the underlying developmental programs. The genes that code for the transcription factors and ...