Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Schuh, Melina Dr."
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Characterisation of primate primordial germ cells in vitro
(2024-06-17)Primordial germ cells (PGCs) are embryonic precursors of sperm and eggs, responsible for passing on genetic and epigenetic information throughout the generations. For certain mammalian species, the development of PGCs can ... -
Coordination of the cell cycle and the cytoskeleton during oocyte meiosis
(2023-06-29)Meiosis serves to reduce ploidy, to half the genetic content of germ cells before they unite again at fertilization. This is achieved by two subsequent divisions called meiosis I and II without an intermittent S-phase. In ... -
Development of methods to decrease aneuploidy in mammalian oocytes
(2022-05-24)Maternal mRNAs accompany and control all processes from the onset of meiosis until the blastocyst stage when the maternal pool of mRNAs is fully replaced by the emryonic mRNA set. The successful development of blastocysts ... -
Molecular Control of Germ Plasm Localization in Zebrafish
(2022-05-24)Germ plasm (GP) consists of a maternally inherited ribonucleo-protein (RNP) condensate, which controls in many animals the formation of germline. Only the cells which contain GP commit to germ cell destinies, whereas all ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ... -
Mechanisms of pronuclear migration in mammalian zygotes
(2019-08-30)In sexually reproducing species, life begins with the fusion of egg and sperm to form the one-cell embryo, called the zygote. Maternal and paternal DNA form the female and male pronuclei, and must migrate to each other to ...