Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Shcherbata, Halyna PD Dr."
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Programmed Translational Readthrough in Drosophila melanogaster
(2020-06-05)Translational readthrough (TR) is extensively used by viruses to expand their limited genome capacity. The pervasiveness of TR across eukaryotic genomes is only recently being explored. Systems biology approaches such as ... -
The impact of the integrated stress response on DNA replication
(2020-05-27)The integrated stress response (ISR) is activated following various stress stimuli which leads to the phosphorylation of the translation initiation factor eIF2alpha. Phosphorylation of eIF2alpha blocks cap−dependent ... -
Evolution of central complex development: Cellular and genetic mechanisms
(2019-11-11)Brains are conserved between insect species, as they consist of a set of anatomically similar areas, or neuropils. Simultaneously, these neuropils differ in size, shape, position and developmental timing between insect ... -
Roles of miR-137 in Muscular Dystrophy and Muscular Dystrophy-Related Phenotypes in Drosophila melanogaster
(2019-05-07)Muscular dystrophies (MDs) are a group of diseases that cause muscular and neurological disorders in human patients. They are associated with a multi-component complex called the Dystrophin Glycoprotein Complex (DGC). The ... -
The nuclear envelope proteins Kugelkern and Narf and their putative role in aging
(2018-10-26)Lamins are type V intermediate filaments and represent the major constituent of the nuclear lamina. Mutations in the laminA/C gene as well as in other nuclear envelope associated proteins lead to a series of human genetic ... -
Novel export and import pathways in S. cerevisiae identified by an engineered SUMO system
(2018-09-07)Nuclear transport receptors (NTRs) mediate the translocation of cargos between the cytoplasm and the nucleus. NTRs are classified either as importins or exportins according to the directionality of the cargo transport. To ... -
Functional characterization of C/D snoRNA-derived microRNAs
(2018-06-26)miRNAs are essential regulators of cell fate and involved in several human diseases, although their biogenesis is a well-accepted paradigm (microprocessor, Exp5, Dicer, and Argonaute). New evidence revealed different ... -
The Tip60 chromatin remodeling complex is required for maintenance and polarity of Drosophila neural stem cells
(2017-10-10)Stem cells are self-renewing cells which produce differentiating offspring during development and tissue homeostasis. Appropriate regulation of stem cell division is highly important to ensure maintenance of the stem cell ...