Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Soeding, Johannes Dr."
Now showing items 1-6 of 6
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Bayesian Inference for Top-Down Protein Markov Models and the Ubiquity of Michaelis-Menten Kinetics
(2024-10-04)The current understanding of protein function predominantly relies on the concept of describing proteins as comprising discrete conformational and chemical states including transitions between these states. The theory of ... -
Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ... -
The role of proteasome generated spliced peptides in the adaptive immune response
(2022-05-20)CD8+ T-cells are the crucial component of the adaptive immune system as they survey the cells of the body for the signs of pathogens or tumours and eliminate them when necessary. To do this, T-cells recognise short antigenic ... -
Chromatin reorganization, signaling responses and non-coding RNA regulators in homeostasis and senescence
(2022-04-21)In mammalian cells, a relatively limited fraction of genetic information is utilized in a variety of ways to give rise to distinct cellular phenotypes. Thus, the genotype essentially acts as input for multilayered regulatory ... -
Discovery and prediction of protein binding sites in DNA and RNA sequences using Bayesian Markov models
(2021-04-23)Transcription factors control the essential step of gene expression via recognizing the over- represented binding sites (or motifs) on the genome. One crucial task is to accurately predict these binding sites on the ...