Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Urlaub, Henning Prof. Dr."
Now showing items 1-20 of 62
-
Development of mass spectrometry-based proteome analysis workflows for the systematic study of cardiac disease research models
(2024-09-26)A specific variant of genetic mutation in the phospholamban gene expresses a cardiac phospholamban protein lacking the arginine amino acid at position 14 (R14Δ-PLN). The mutation is believed to have a founder in the ... -
Characterization of Novel Proteins Modulating the Nanoscale Organization of the Membrane-Associated Periodic Skeleton in Neurons
(2024-09-19)The Membrane-associated Periodic Skeleton (MPS) is a lattice located underneath the neuronal plasma membrane, characterized by a distinctive ~190 nm periodic architecture imposed by the nanoscale arrangement of its main ... -
Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis
(2024-07-23)Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ... -
Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
Mechanism of non-canonical ubiquitination by ubiquitin conjugating enzyme Ubc6
(2023-10-18)Protein quality control by ubiquitination occurs due to the sequential action of three enzyme classes: ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligases (E3). Conventionally, ubiquitin (Ub) ... -
Analysis of multifunctional RNA helicase regulation by protein cofactors in different gene expression processes
(2023-09-11)The biogenesis of ribonucleoprotein (RNP) complexes is a fundamental process in the gene expression network. Assembly of eukaryotic ribosomes and spliceosomes is highly orchestrated and entails the formation of numerous ... -
The role of TRIP13 in DNA damage repair
(2023-08-10)Double-strand breaks, the most toxic DNA lesions, can be repaired via homologous recombination or non-homologous end joining (NHEJ). Using the right pathway at the right time is crucial to maintain genome integrity. ... -
Coordination of the cell cycle and the cytoskeleton during oocyte meiosis
(2023-06-29)Meiosis serves to reduce ploidy, to half the genetic content of germ cells before they unite again at fertilization. This is achieved by two subsequent divisions called meiosis I and II without an intermittent S-phase. In ... -
Actin promotes chromosome aggregation and accurate chromosome segregation in mammalian oocytes
(2022-09-15)Accurate chromosome segregation during meiosis is essential for the formation of a new life. During meiosis, spindle microtubules bind to the chromosomes’ kinetochores and arms in order to separate the genetic material. ... -
Regulation of vesicular trafficking in presence of mutations in contractile proteins
(2022-06-20)The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ... -
The role of proteasome generated spliced peptides in the adaptive immune response
(2022-05-20)CD8+ T-cells are the crucial component of the adaptive immune system as they survey the cells of the body for the signs of pathogens or tumours and eliminate them when necessary. To do this, T-cells recognise short antigenic ... -
Protein Interactions in minimal cells
(2022-05-18)Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ... -
The role of GTPases in human mitochondrial ribosome biogenesis
(2022-05-03)Mitochondria are essential organelles of eukaryotic cells, which produce the vast majority of the cellular ATP via oxidative phosphorylation (OXPHOS). The mitochondrial gene expression machinery contributes to the formation ... -
Purification of organellar macromolecular complexes for structural biology
(2022-03-14)Photosynthesis is the source of life on Earth. In oxygenic photosynthesis, water and carbon dioxide are converted into organic matter using of solar energy that results in the release of oxygen. PSII, a supra-molecular ... -
Structural Insights into Early Spliceosome Assembly by cryo-EM
(2021-12-23)In eukaryotes, splicing is a process during which the non-coding introns of the pre-messenger RNA (pre-mRNA) are removed, and the protein-coding exons are ligated. The introns are defined by conserved 5' splice site (5'SS), ... -
Implementation of chemical protein-nucleic acid cross-linking into mass spectrometric workflows and mass spectrometric database searches
(2021-11-22)Protein nucleic acid interactions play a pivotal role in cells, from transcription to translation. Functions of proteins in protein nucleic acid interactions are diverse: histones are responsible for the packaging of the ... -
Post-Translational Protein Modifications involved in Exo- and Endocytosis of Synaptic Vesicles
(2021-10-26)Neurotransmitter release is a key step that enables information flow between the pre- and post-synapse. However, regulation of the neurotransmitter release remains an intricate and widely unexplored matter despite recent ... -
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases
(2021-10-19)Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific ... -
Vimentin Intermediate Filament Softening - Recovery Behavior and Post-Translational Modifications
(2021-09-16)The capability of eukaryotic cells to resist large deformations, to transport intracellular cargo and to adapt the cell shape, for example during migration, depends on the cytoskeleton, a composite network of three types ... -
Structural investigation of functional nucleic acids
(2021-06-30)DNA enzymes, also known as deoxyribozymes, are synthetic single-stranded DNA molecules able to catalyze chemical reactions. There are two main reasons for studying deoxyribozymes: their practical value in various applications, ...