Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Wintermeyer, Wolfgang Prof. Dr."
Now showing items 1-6 of 6
-
Elongation factor P: mechanism of action and opportunities for drug design
(2023-07-24)EF-P is a conserved protein that has shape similarity to the tRNAs and binds to the E site of the ribosome. EF-P enhances the rate of peptide bond formation during the synthesis of polyPro sequences. In E. coli one third ... -
Co-translational processing and membrane insertion of proteins in bacteria
(2022-11-04)Protein biogenesis entails the synthesis of polypeptides on the ribosome, their co- and post-translational maturation, folding, and, in the case of membrane proteins, insertion into the lipid bilayer. Bacterial proteins ... -
Monitoring the late events of translation initiation in real-time
(2016-10-19)In bacteria, translation initiation is promoted by three initiation factors (IF1, IF2 and IF3) and entails three distinct steps. First, the small ribosomal subunit (30S) recruits the initiation factors, initiator tRNA ... -
Dynamic interactions during ribosome targeting to the membrane
(2015-05-11)The signal recognition particle (SRP) and its receptor are the main components of the co-translational protein targeting pathway by which membrane proteins are targeted to the membrane. The co-translational targeting pathway ... -
Interaction of the SecYEG translocon with the SRP receptor and the ribosome
(2015-05-08)This work aimed at studying the interaction between SecYEG and FtsY and before and after the translating ribosome has been transferred to the SecYEG translocon. In this study we have used monomers of the SecYEG complex ... -
Structural and functional studies of eukaryotic translation initiation factors
(2014-08-19)Protein synthesis can be divided into three distinct subprocesses, namely initiation, elongation and termination. During the initiation phase, the elongation competent ribosome, which harbors the initiator tRNA in its ...