Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Zeisberg, Michael Prof. Dr."
Now showing items 1-4 of 4
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NFATc1 driven ER-stress responses in the progression of non-alcoholic fatty liver disease
(2021-06-30)Non-alcoholic fatty liver disease (NAFLD) mirrors the hepatic manifestation of the metabolic syndrome and is defined by progressive fat accumulation in hepatocytes (steatosis). Uncomplicated NAFLD may progress to a severe ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
A regulatory network of Mdm2 and members of the Polycomb Group (PcG) family
(2016-01-22)The E3 ubiquitin ligase MDM2 is the most well-known physiological antagonist of the tumor suppressor P53. P53 induces cell cycle arrest or apoptosis in the case of DNA damage, whereas MDM2 targets it for proteasomal ... -
Role of endogenous retrovirus promoter activity in tumor suppression
(2015-06-03)Roughly 8% of the human genome consists of human endogenous retroviruses (HERVs). They are believed to be remnants of ancient retroviral infections of the germline that were passed on from one generation to the next over ...