Blättern nach Typ "cumulativeThesis"
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Extending the classical histological routine through microcomputed tomography imaging and multimodal image processing
(2024-04-08)Histological analysis has proven to be the de facto gold standard for the characterization of hard and soft tissue samples at cellular resolution in both clinical routine and biomedical research. After the tissue sample ... -
Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ... -
Gesundheitsbezogene Lebensqualität von Kindern, Jugendlichen und Erwachsenen nach einem Schädel-Hirn-Trauma
(2023-12-07)Traumatic brain injury (TBI) is considered as a major burden on public healthcare systems worldwide. The negative consequences of TBI might affect various aspects of people’s lives, leading to enormous negative effects on ... -
Defining the Role of Chromatin Remodeling Complexes in Control of Master Transcription Factor Networks in Pancreatic Cancer Subtype Switch
(2023-10-19)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease characterized by a dismal prognosis of 11%, projected to be the second-leading cause of cancer-related death by 2040. This urgent clinical challenge ... -
Physical activity and developmental psychopathology in children and adolescents: cross-sectional, longitudinal follow-up and concurrent developmental relationships
(2023-09-26)The current cumulative dissertation aimed to investigate the cross-sectional and longitudinal relationships between mental health problems, including symptoms of ADHD, and physical activity (PA) in children and adolescents. ... -
Modulation of HSF1 activity by p53 and its impact in cancer therapies
(2023-07-13)The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ... -
Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
Klinische und polysomnografische Charakteristika von Patienten mit Restless-Legs-Syndrom unter Augmentation
(2023-05-30)Restless legs syndrome (RLS), as a circadian movement disorder, can have a high impact on the quality of sleep and everyday life. For RLS-treatment multiple substances including dopamine agonists are recommended in the ... -
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
(2023-05-02)Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, ... -
Methods for Blinded Sample Size Recalculation in Adaptive Enrichment Designs
(2022-12-21)In precision medicine the potential heterogeneity of patient populations becomes more accessible through technical and medical innovations. A population might be heterogeneous and different strata may in turn respond ... -
In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
Interfering with critical steps of the viral replication cycle to diminish SARS-CoV-2 propagation
(2022-10-07)The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has so far infected more than 0.5 billion people worldwide, with at least 6.3 million deaths, and constitutes one of the largest global health ... -
Gene-expression control in early and late-onset dementia
(2022-10-05)Mutations in genes that control epigenetic gene expression, especially the machinery that controls Histone 3 lysine 4 (H3K4me) methylation, are over-represented in intellectual disability disorders. It is mediated by both ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
Extracellular vesicles derived from adipose mesenchymal stem cells (AMSCs) reduce autophagic flux via microRNA-25-3p transfer after ischemic stroke
(2022-03-03)Causal therapy of ischemic stroke remains available to only a minority of patients despite the success of systemic thrombolysis and thrombectomy. Consequently, new adjuvant therapeutic options are urgently needed. MSC ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Investigating the Mechanistic role of Ykt6 in Wnt Trafficking and Cell cycle Progression
(2021-09-28)Ykt6 is an evolutionarily conserved R-SNARE that mediates vesicle fusion events at diverse cellular compartments of secretory, endocytic and autophagy pathways. It is known to be required for the secretion of Wnts on ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
HSP90-stabilized proteins as therapeutic targets in cancer
(2021-06-25)Although cancer is among the most common causes of death worldwide, successful treatment options for most cancer entities remain elusive, raising the need for novel therapies. One attractive target of current drug candidates ... -
Ethische Implikationen der Prädiktion und Früherkennung einer Late-onset-Demenz
(2021-06-24)The focus on diagnosing dementia as early as possible has entered clinical practice, often supported by the use of an increasing number of available biomarkers. New diagnostics in this topic area are the subject of intense ...