Blättern Human- und Zahnmedizin nach Betreuer & Gutachter "El-Armouche, Ali Prof. Dr."
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Die Rolle des Protein-Phosphatase-1-Inhibitor-1 in der β-adrenergen Signalkaskade kardialer Fibroblasten
(2019-03-26)Heart failure is among the most common internal diseases in industrialized nations and associated with a high mortality rate. The sympathetic nervous system and β-adrenergic signaling play a crucial role in the pathophysiology ... -
Effekte einer chronischen β-Adrenozeptor-Blockade auf die Aktivität der Calcium-Calmodulin-Kinase II in der Herzinsuffizienz
(2018-01-22)Heart failure is one of the leading causes of mortality worldwide. Despite major advances in the understanding of heart failure pathophysiology and significant progress in the development of therapeutic concepts, the ... -
Rolle der Phosphodiesterase 2 in der menschlichen und experimentellen Herzinsuffizienz
(2017-09-14)Background: Cyclic nucleotide phosphodiesterases (PDEs) compromise a family of cyclic-nucleotide hydrolysing enzymes, controlling the levels of cAMP and cGMP in a highly specific and stimulus-dependent manner. Amongst them, ... -
Analyse des antifibrotischen Potenzials der betaadrenergen Signalkaskade und des PKA-Effektors Protein-Phosphatase-Inhibitor-1
(2017-05-17)The fibrotic remodeling of the heart appears in several cardiac diseases. Especially fibroblasts, which are known as the tissue producing cells in the heart, contribute to this process. Interacting with cardiomyocytes they ... -
Kardiale Phänotypisierung einer transgenen Mauslinie mit herzspezifischer Calcium-Calmodulin-Kinase IIδc- Überexpression auf einem Phosphatase-Inhibitor-1- Knockout-Hintergrund
(2015-09-29)Since years cardiovascular diseases are the leading cause of death in our population. In particular heart failure is of considerable importance. So, to understand molecular alterations in signal transduction and to identify ... -
Functional roles for chromogranin B
(2013-11-29)The versatility of intracellular calcium as a second messenger is evident by its ability to mediate such opposing events as neuronal cell growth and apoptosis. One leading hypothesis is that calcium regulates such divergent ... -
Die Genregulation des myokardialen Na+/Ca2+-Austauschers
(2013-10-16)Alpha1-adrenergic stimulation and mechanical load are considered crucial for the expression of sarcolemmal Na+/Ca2+ exchanger (NCX1). However, the interaction between these processes is unknown. We investigated electrically ... -
Die Rolle des späten Natrium-Stroms bei der Kalzium-Calmodulin-abhängigen ProteinkinaseIIδC (CaMKIIδC)-induzierten Herzinsuffizienz und beim chronischen Vorhofflimmern
(2012-06-21)Ranolazine is a drug that was introduced for antianginal therapy in Germany in 2008. Its effects are explained by inhibition of the so called „late Na+-current“ in the cardiomyocyte. Contrary to the „fast Na+-current“, ... -
Vergleich des kardialen Remodelings zwischen Vorlastmodell und Nachlastmodell
(2011-08-24)In the group of cardiovascular diseases heart failure is the most common disease. Hemodynamic overload is an important component part of the development of cardiac hypertrophy and heart ... -
Einfluss der Calstabin2-Mutante FKBP12.6D37S in gesunden Mauskardiomyozyten und in einem transgenen Herzinsuffizienzmodell, das die Kalzium/Calmodulin-abhängige Proteinkinase IIδc überexprimiert
(2011-08-24)In heart failure (HF) calcium/calmodulin-dependent protein kinase IIdc (CaMKIIdc) and protein kinase A (PKA) are activated and promote diastolic sarcoplasmic reticulum (SR) calcium (Ca) ... -
Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
(2011-03-18)In human hearts, the transition from cardiac hypertrophy to advanced heart failure (HF) is accompanied by a tremendous increase in Akt phosphorylation. In non-myocardial tissue, the ... -
Modifikation des Hypertrophie-Phänotyps der Myosin-Bindungs-Protein-C defizienten Maus durch Muscle-LIM-Protein
(2011-02-18)Modification of the hypertrophy-phenotype in Myosin-Binding-Protein-C-deficient mice by Muscle-LIM-Protein Approximately 3% of all citizens in the old West German States are affected by ... -
Induktion von myokardialem ER-Stress durch biomechanische Last und neurohumorale Stimulation.
(2010-08-03)Myocardial hypertrophy is an important adaptive response to various physiological and pathological stimuli. It can progress to maladaptive hypertrophy and finally heart failure. It is ...