Blättern Human- und Zahnmedizin nach Betreuer & Gutachter "Nau, Roland Prof. Dr."
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Individuelle Risikofaktoren für C.-difficile-Infektionen bei stationären geriatrischen Patienten im Ev. Krankenhaus Göttingen-Weende
(2023-12-04)Background: C. difficile infection (CDI) is one of the most common nosocomial diseases worldwide. It is transmitted faecal-orally by spores of toxin-producing Clostridioides difficile (TCD), which are particularly prevalent ... -
Prospektive Untersuchung, liquoranalytische Aspekte und Evaluation präanalytischer Bedingungen der CXCL13-Analytik bei Patienten mit akuter Neuroborreliose
(2023-11-17)From July 2014 to August 2019, we examined the clinical characteristics and CSF findings of 72 patients (64 adults, 8 children) with neuroborreliosis as part of a prospective study. According to the modified DGN criteria, ... -
Anwendung von Inhalatoren und hierdurch bedingte Symptomkontrolle sowie Verbesserung der Lungenfunktion bei geriatrischen Patienten mit chronisch-obstruktiver Lungenerkrankung
(2022-03-08)Purpose The use of inhalers requires a high degree of fine motor skills and coordination, which is particularly difficult for elderly patients suffering from chronic-obstructive pulmonary disease (COPD). Many of these ... -
Auswirkung von Glycopyrronium auf die Phagozytose von Streptococcus pneumoniae und Escherichia coli durch Makrophagen und Mikrogliazellen
(2021-11-10)Streptococcus pneumoniae and Escherichia coli are responsible for a wide variety of life-threatening infections such as pneumonia, sepsis, and meningitis. Multi-resistant pathogens are spreading more and more despite the ... -
Prävalenz, Antibiotikaresistenz und klinische Relevanz einer Besiedlung des Respirationstraktes mit Streptococcus pneumoniae in einer geriatrischen Klinik
(2020-11-25)Colonization of the pharynx by Streptococcus pneumoniae was studied in 185 in-hospital geriatric patients (median age 81 years) from 29 March 2011 to 22 June 2011. Swabs were plated on blood agar plates. Colonies with a ... -
Effekt einer Palmitoylethanolamid-Prophylaxe auf alte oder neutropenische Mäuse nach intrazerebraler E. coli-Infektion
(2020-02-19)Easy-to-achieve interventions to promote healthy longevity are desired to diminish the incidence and severity of infections, as well as associated disability upon recovery. The dietary supplement palmitoylethanolamide ...
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Beeinflussung des Verlaufs von Pneumokokken-Meningitis in Mäusen durch Stimulation mit einem Cytosin-Guanin-haltigen Oligonukleotid
(2020-01-28)Streptococcus pneumoniae is the most common cause of bacterial meningitis in small children, the elderly and in immunocompromised patients. The aim of this study was therefore, to test if a single intraperitoneal injection ... -
Psychopharmaka und das Risiko von Stürzen in der stationären geriatrischen Versorgung
(2019-08-15)Abstract OBJECTIVE: To examine the impact of medication and medical conditions on the fall risk in older hospitalized patients. DESIGN: Matched case-control study. SETTING: Large regional hospital in a mid-sized ... -
Die Verordnung von Schlaf- und Beruhigungsmitteln: Ein Mixed-methods-Ansatz zur Exploration einer Drucksituation
(2018-12-18)Background. Benzodiazepines and Z-drugs are frequently prescribed for more extended periods than recommended despite the potential risks for patients. To identify a lack of knowledge as a crucial factor would be insufficient. ... -
Verordnung von Antidepressiva und Neuroleptika bei ≥ 65-Jährigen in einem Krankenhaus der Grund- und Regelversorgung
(2017-11-27)BACKGROUND: Many elderly patients receive antidepressants and neuroleptics, although treatment with these psychotropic agents is associated with serious side effects including an increased risk of falls and fractures as ... -
Hausbesuch oder Visite – wie erleben Hausärzte und Pflegekräfte den Heimbesuch im Pflegeheim?
(2017-08-21)Background: The increasing number of residents in nursing homes and their complex health status will challenge medical care and the interaction between nurses and general practition-ers (GPs). The nursing home visit is a ... -
Einfluss der Gebrechlichkeit auf Morbidität und Mortalität nach kathetergestützter Aortenklappenimplantation (TAVI)
(2017-06-15)Background: Transcatheter aortic valve implantation (TAVI) represents a less invasive treatment option for elderly patients. Therefore, we aimed to determine the impact of frailty measured by Katz Index of Activities of ... -
Untersuchungen zu Aquaporin 1 und Aquaporin 4 im Liquor von Patienten mit bakterieller und viraler Meningitis im Vergleich zu einer Kontrollgruppe
(2016-09-06)Background: The bacterial meningitis has a lethality of 10-20%. A brain edema was developed by 14% of the patients with bacterial meningitis. Current research is looking into the importance of aquaporines for the development ... -
Sequentielle Antibiose mit Rifampicin gefolgt von Ceftriaxon als neuroprotektiver Therapieansatz bei der bakteriellen Meningitis
(2016-06-24)Abstract OBJECTIVE: In bacterial meningitis, severe systemic and local inflammation causes long-term impairment and death of affected patients. The current antibiotic therapy relies on cell wall-active beta-lactam ... -
Die Rolle verschiedener Virulenzfaktoren von Streptococcus pneumoniae bei der Meningitis: Untersuchung am Mausmodell
(2015-09-11)The present study examines virulence factors of S. pneumoniae in mouse model. After intracerebral injection virulence factors of D39-wild-type S. pneumoniae were compared with isogenetic derivates. These infection strains ... -
Mikroglia-Aktivierung durch Bestandteile von <i>Borrelia burgdorferi sensu lato</i>
(2015-04-15)Lyme disease is the most commonly reported vector-borne illness. It is caused by bacteria of the Borrelia family and transmitted by infected ticks. The outer surface protein C (OspC) and the flagellar protein p41 are common ... -
Lumbalpunktionsbefunde bei geriatrischen Patienten im Zeitraum 2008-2011
(2014-12-12)BACKGROUND: The chemical composition of the cerebrospinal fluid (CSF) is age-dependent. METHODS: Routine CSF parameters, the indications for lumbar puncture (LP), and the most frequent complications were retrospectively ... -
Activation of murine microglial cells by muramyl dipeptide alone and in combination with Toll-like receptor agonists
(2014-09-25)Meningitis, meningoencephalitis and sepsis are severe diseases causing many deaths all over the world every year. Escherichia coli (E. coli) is the most common Gram-negative bacterium causing neonatal meningitis and sepsis ... -
Immunreaktionen im zentralen Nervensystem bei Stimulation mit Bestandteilen von Borrelia burgdorferi
(2014-01-06)Stimulation of the CNS in vivo and in vitro with proteins from Borrelia burgdorferi. -
Beeinflussung der Phagozytose von Pneumokokken durch Mikrogliazellen mit Anticholinergika
(2013-12-16)Streptococcus pneumoniae is the most common pathogen causing bacterial meningitis. Despite all efforts using the treatments available, pneumococcal meningitis proves fatal in 25 % of cases. Increasing resistance to ...