Browsing Human- und Zahnmedizin by Advisor "Bickeböller, Heike Prof. Dr."
Now showing items 1-8 of 8
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Genome-wide association studies and follow-up kernel approaches in the longitudinal PsyCourse Study
(2023-02-23)A genetic association study is a popular method to analyse the connection of genomic factors with disorders or disease-related phenotypes. There are various study types including genome-wide association studies (GWASs) and ... -
Association Analysis Using Set-Based Approaches in the Post-GWAS Era
(2021-08-10)Genotyping arrays have greatly facilitated genetic epidemiological studies into genetic risk factors for numerous complex diseases such as psychiatric disorders. The use of genome-wide association analysis (GWAS) is ... -
Kernel-Based Pathway Approaches for Testing and Selection
(2017-10-12)With the number of single nucleotide polymorphisms (SNPs) available in genetic data currently constantly increasing, the evaluation of SNP sets has become a successful approach toward elucidating the genetic influence on ... -
Gene-Set Meta-Analysis to Discover Molecular-Biological Pathways Associated to Lung Cancer
(2017-06-09)During the last two decades the search for risk factors of many human diseases turned into a new direction, since it got feasible to gauge the human genome. Genome-wide association studies (GWAS) were carried out to identify ... -
Gene-Environment Interaction and Extension to Empirical Hierarchical Bayes Models in Genome-Wide Association Studies
(2014-07-24)There are over 100,000 human diseases of which only around 10,000 are known to be monogenic, resulting from modification in a single gene. Many multifactorial diseases, such as cancer and lung cancer in particular, are ... -
Kernel Methods for Genes and Networks to Study Genome-Wide Associations of Lung Cancer and Rheumatoid Arthritis
(2014-02-28)The search for genetic causes of common complex diseases has been revolutionized by the ability to genotype exceptionally large numbers of single nucleotide polymorphisms (SNPs) in hundreds of individuals at an affordable ... -
Assessing prediction error of genetic variants in Cox regression models
(2012-04-30)Genetic studies focus on the identification of genetic variants in association with development of disease. Recently, there has been special interest in predicting outcomes based on genetic risk scores and interest in ... -
FLK50-Score zur Vorhersage des Lungenkrebsrisikos bis-50jähriger Probanden. Eine methodische Arbeit auf Basis einer Familienstudie
(2012-01-26)Lung cancer is one of the most common causes of death in Germany. Since the prognosis remains poor, its prevention is of particular significance. Persons at high risk profit most from ...