Blättern Human- und Zahnmedizin nach "Döppner, Prof. Dr. Thorsten Roland" Betreuer
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Der Einfluss der Fettsäuresynthese auf die neuronale Schädigung nach Hypoxie und zerebraler Ischämie
(2022-04-22)In the context of a stroke, a cascade of reactions is induced at the cellular level, resulting in inflammation and apoptosis. Fatty acids play a pivotal role in cell metabolism - they can be generated de novo from carbon ... -
Extracellular vesicles derived from neural progenitor cells stimulate neuroregeneration in a rodent stroke model
(2022-03-02)Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, ... -
Hypoxic Microglial Extracellular Vesicles Abrogate Poststroke AQP4 Depolarization, Astrogliosis and Neuroinflammation
(2023-11-03)Reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation occurring and lasting for a long time in the periinfarct region are associated with poststroke brain injury. Our previous work has revealed ... -
Poststroke lipid droplet accumulation in residing microglia and its influence on inflammation
(2023-10-20)Microglia are critically involved in poststroke inflammation and thus affect neurological outcomes. Lipid droplet (LD) accumulation of microglia is dysfunctional in the aged brain and contributes to the worse outcome of ...