Browsing Human- und Zahnmedizin by Advisor "Dihazi, Hassan Prof. Dr."
Now showing items 1-11 of 11
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Characterization of urine proteome pattern changes associated with early diabetic nephropathy: a proteomic approach
(2024-04-19)Type 2 diabetes mellitus has become the most common cause of kidney failure in Europe and the United States. In Germany, 8.7 million people live with type 2 diabetes, although an estimated two million more affected people ... -
Proteomische Analyse der Nephrotoxizität im Falle der Cyclosporin A und Tacrolimus Therapie
(2023-05-03)Immunosuppressants have made organ transplantation possible as a therapeutic intervention. One of the first and still most important groups of drugs among immunosuppressants are the calcineurin inhibitors, including ... -
Sezernierte Proteindisulfidisomerase ERp57 als potenziell profibrotischer Faktor in der Nierenschädigung
(2023-04-03)Today many people suffer from chronic kidney diseases (CKD), which often lead to renal fibrosis and kidney failure. For this reason dialysis or renal transplantation often become indispensable to life. There are still ... -
Oxidative stress in the pathogenesis of renal injury: the effect of the antioxidant danshensu on renal fibrosis
(2022-11-29)Chronic kidney disease (CKD), often manifested in its end-stage as renal fibrosis, is a widespread illness, for example in children following congenital urinary obstruction and in adults due to an increasing number of ... -
Untersuchung der Rolle des löslichen E-Cadherins in der Nierenschädigung/-heilung
(2021-04-21)Diabetic nephropathy is a microvascular complication of diabetes mellitus and an important cause of chronic kidney disease. It is characterized by an increased cardiovascular risk and progression to terminal renal failure. ... -
Die Rolle von Calretikulin, einem kalziumbindenden Chaperon, in der Progression des Nierenzellkarzinoms
(2021-02-24)Metastatic renal cell carcinoma (mRCC) still has poor outcome despite new emerging therapies and is considered chemoresistant. The calcium-binding chaperone Calreticulin (CALR) is involved in the progression of different ... -
Die Rolle der Proteindisulfidisomerase ERp57 in der Chemoresistenz des Nierenzellkarzinoms
(2019-03-14)It is well-known that renal cell carcinoma is resistant to conventional chemotherapeutic drugs. In the past serious investigation has been made to understand the underlying pathomechanisms. To analyse the mechanism of ... -
Peroxisomes and Kidney Damage
(2014-12-12)This work examined (a) how the endotoxic stress affects peroxisomal function and autophagic degradation of peroxisomes-pexophagy, (b) how a superimposed dysfunction of lysosomes and pexophagy modifies responses to ... -
Untersuchung der Proteinmusterveränderungen renaler Fibroblasten nach TGFß-1-Behandlung
(2014-03-10)Renal fibrosis is characterized by excessive accumulation of extracellular matrix. It is associated with a declining renal function. The molecular mechanisms of the renal fibrosis are still not completely understood. Here ... -
Proteomische Analyse eines in-vitro-Modells für die interstitielle renale Fibrose: Der osmotische Stress als Fibrose-triggernder Faktor
(2012-07-27)Renal fibrosis (RF) is the final stage of many renal diseases leading to organ function loss. RF is characterised by the deposition and accumulation of extracellular matrix components (ECM). Renal fibroblasts are playing ... -
L-FABP und H-FABP als neue prognostische Biomarker für den Beginn einer Nierenersatztherapie im Falle eines akuten Nierenversagens
(2012-03-08)Acute kidney injury (AKI) has an important meaning in modern medicine. A lot of surveys could demonstrate that acute kidney injury is an independent risk factor for mortality. Despite the ...