Blättern Human- und Zahnmedizin nach "Figura, Kurt von Prof. Dr. Dr. h.c." Betreuer
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Herstellung zweier Gene-Targeting-Vektoren zur Generierung von Mausmodellen für CDG-Ia mit den Mutationen F115L und R137H im PMM2-Gen
(2012-11-27)CDG-Ia is a metabolic disease caused by mutations in the gene encoding phosphomannomutase II (PMM2) and affecting the glycosylation pathway of glycoproteins. The topic of this paper is the construction of two gene ... -
Mechanism of pFGE and FGE Retention in Endoplasmic Reticulum
(2007-03-05)The formylglycine generating enzyme FGE, encoded by SUMF1 gene (Sulfatase modifying factor 1) performs a novel co-translational modification of a specific cysteine residue to formylglycine ... -
Posttranslational generation of C-alpha-formylglycin in eukaryotic sulfatases: development of the biochemical approach for the characterisation and purification of the modifying enzymee
(2003-07-15)Sulfatases carry at their active site a C Ñ-formylglycine (FGly) residue that is essential for enzyme activity. The formyl group of this FGly is directly involved in sulfate ester cleavage. ... -
Requirement of HSP70s in the cytosol to vacuole transport of aminopeptidase 1 in Saccharomyces cerevisiae
(2000-10-27)In Saccharomyces cerevisiae, aminopeptidase 1 (Ape1p) is a vacuolar resident protein which is transported to the vacuole by a non classical pathway. On synthesis in the cytoplasm the ...