Blättern Human- und Zahnmedizin nach "Friede, Tim Prof. Dr." Betreuer
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Identification of biomarker-defined populations in precision medicine
(2023-03-24)The aim of precision medicine is to identify the treatment that provides the best response for a patient. For this purpose, predictive biomarkers play a crucial role. Due to their ability to define subgroups of patients ... -
Methods for Blinded Sample Size Recalculation in Adaptive Enrichment Designs
(2022-12-21)In precision medicine the potential heterogeneity of patient populations becomes more accessible through technical and medical innovations. A population might be heterogeneous and different strata may in turn respond ... -
Nephrotoxizität bei immunsuppressiver Therapie nach Lebertransplantation Ein systematischer Review und Metaanalyse
(2022-11-22)It is known that calcineurin inhibitors (CNI), tacrolimus and cyclosporine have acute and chronic nephrotoxic effects. Liver transplant recipients get CNI after transplantation. Therefore, are used to spare CNI other ... -
Blinded Sample Size Re-estimation for Longitudinal Overdispersed Count Data in Randomized Clinical Trials with an Application in Multiple Sclerosis
(2021-02-22)In many clinical experiments, particularly in randomized clinical trials, the sample size required needs to be assessed and justified. For calculating a clinical trial’s sample size, assumptions have to be made regarding ... -
Bayesian methods for borrowing information in clinical drug development
(2020-12-11)Clinical drug development is the process of investigating potential pharmaceutical therapies in clinical trials. The clinical investigation of drugs consists of four phases. The aim is bringing a candidate drug from early ... -
Planung multizentrischer randomisierter klinischer Studien mit kontinuierlichem Endpunkt
(2020-03-31)Multicentre controlled randomized clinical trials are a cornerstone of modern evidence-based medicine. The benefits of collecting data from more than one centre are numerous, including accelerated recruitment and better ... -
Methodologische Aspekte bei Placebo-kontrollierten randomisierten Crossover-Studien zu chronischen Schmerzerkrankungen
(2020-02-17)Abstracts are an established and typically freely available part of medical science original papers. They allow the reader to quickly access the most important study content. Therefore, it is very important that abstracts ... -
Adaptive designs for clinical trials in cardiovascular diseases
(2018-12-07)Cardiovascular diseases are diseases of the heart and blood vessels constituting a major cause of death and disability worldwide. Cardiovascular drug development aims to deliver efficacious drugs to address the public ... -
Interleukin-2-Rezeptor-Antagonisten für pädiatrische und adulte Lebertransplantatempfänger: Systematische Reviews und Meta-Analysen kontrollierter Studien
(2016-11-07)Interleukin-2 receptor antagonists (IL-2RA) are monoclonal anti-CD25 immunoglobulin G (IgG) antibodies, which specifically bind and block the IL-2 receptor of activated T-lymphocytes. They decrease statistical significant ... -
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis
(2014-01-21)Recent studies have shown a decrease in annualized relapse rates (ARRs) in placebo groups of randomized controlled trials (RCTs) in relapsing multiple sclerosis (RMS). This dissertation aimed to describe this trend ...