Blättern Human- und Zahnmedizin nach "Gross, Oliver Prof. Dr." Betreuer
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Detektion diagnostischer Frühmarker der Nierenfibrose im Urin von Patienten mit Alport-Syndrom mittels proteomischer Methoden
(2024-02-02)Detection of early diagnostic tools of kidney sclerosis in the urine of patients with Alport-Syndrome using proteomic methods. -
Einfluss früher medikamentöser Intervention auf Krankheitsverlauf und Zeitpunkt des Nierenversagens bei Patienten mit Alport-Syndrom mit einer p.(Gly624Asp)-Variante im COL4A5-Gen
(2023-07-13)Background: ACE-inhibitors (ACEis) and AT1-Antagonist (ARBs) have been established as an effective treatment of Alport syndrome (AS). However, it remained unclear at which stage therapy should be initiated. The present ... -
Entwicklung von Nierenfunktion und Nierenschädigung bei Patienten mit Alport-Syndrom in Abhängigkeit des Beginns einer nephroprotektiven Therapie
(2023-03-28)Alport syndrome is a hereditary collagen type IV disease which affects kidneys, eyes and hearing. The extent of kidney involvement is prognostically relevant; if left untreated, terminal kidney failure can occur at an early ... -
Auswirkung von ACE-Hemmern auf die Nierenfunktion bei hereditären Nierenerkrankungen wie dem Alport-Syndrom im Mausmodell
(2022-04-22)Alport syndrome is a hereditary kidney disease that leads to the development of progressive kidney failure. It is based on mutations in the COL4 genes. Homozygous or hemizygous patients develop the disease earlier and more ... -
Einfluss von salzreicher Ernährung auf die hyperperfundierte Niere nach Uninephrektomie bei hereditären Nierenerkrankungen wie dem Alport-Syndrom im Mausmodell
(2021-08-12)The filtration function of the kidney in the glomerulum consists of the endothelial cell, basement membrane (GBM) and podocyte. Collagen IV is, among other things, a major component of GBM. Homozygous mutations in type IV ... -
BKV-Infektion bei nierentransplantierten Patienten - eine retrospektive Analyse vor und nach Etablierung eines Screeningverfahrens
(2021-02-05)Background: The kidney transplantation is the therapy of choice for patients with end-stage kidney disease. The necessary use of immunosuppressive agents after transplantation causes an increased susceptibility to infections. ... -
Complementinhibition mittels Eculizumab verstärkt den nephroprotektiven Effekt von ACE-Inhibitoren in einem COL4A3-Knockout-Mausmodell für das Alport-Syndrom
(2020-02-14)Alport syndrome (AS) is a hereditary disease associated with progressive renal failure and kidney fibrosis. The disease is caused by mutations in genes encoding for either the α3, 4 or 5 chain of type IV collagen, which ... -
Der langfristige Effekt einer RAAS-Blockade auf den Krankheitsverlauf bei heterozygoten Mutationsträgern des Alport-Syndroms
(2020-02-11)Alport Syndrome (AS) is a hereditary disease that leads to a progressive loss of glomerular basement membrane function due to mutations in collagen IV, but AS is also associated with extra renal symptoms such as hearing ... -
Prospektive Verlaufsstudie über die Auswirkung der RAAS-Blockade bei Trägern des Alport-Syndroms
(2018-07-05)The aim of the present study was the prospective follow-up of Alport patients with regard to disease progression. A main focus was on the consideration of the different therapy groups, which were divided after the start ... -
Die Bedeutung der glomerulären Basalmembrankomponente Nidogen-1 bei podozytären Erkrankungen der Niere
(2017-05-22)The basement membrane composition of the glomeruli is an important factor in the pathogenesis of many renal diseases. The understanding of the interactions of the BM components and the pathogenesis of glomerular renal ... -
Nidogen-2 in der Pathogenese Kollagen IV-assoziierter Nephropathien bei zusätzlicher Podocin-Mutation
(2016-11-21)Collagen IV-related nephropathies are hereditary diseases affecting the glomerular basement membrane. Homozygous aberrations of COL4A3 or COL4A4 gene or X-linked mutations of COL4A5 gene are responsible for Alport syndrome ... -
Nierenschützende Wirkung von Calcitriol additiv zu Ramipril auf die Nierenfibrose im AlportMaus-Modell
(2016-03-01)Background: Alport syndrome (AS) is a hereditary, progressive, glomerular nephritis that leads to end-stage renal disease in young adult life. AS is a rare and presently uncurable condition; available treatments tackle ... -
Prognose von Patienten mit Alport-Syndrom unter Berücksichtigung einer medikamentösen Intervention und verschiedener Nierenersatzverfahren
(2015-01-20)Alport syndrome is a hereditary kidney disease which typically has a progressive course (Alport 1927). Several extrarenal symptoms such as inner ear hearing loss and a specific eye disease known as „Lenticonus“ can also ... -
Neue Therapieansätze für das Alport-Syndrom: Nephroprotektives, antifibrotisches und antiinflammatorisches Potential von Paricalcitol additiv zu Ramipril in einem Mausmodell für progressive Nierenfibrose
(2014-07-25)Background: Alport syndrome (AS) is a hereditary, progressive, glomerular nephritis that leads to end-stage renal disease in young adult life. AS is a rare and presently uncurable condition; available treatments tackle ... -
Der Einfluss des DDR1+/-/NPHS2+/R140Q-Genotyps auf die Interaktion zwischen glomerulärer Basalmembran und Schlitzmembran im Tiermodell
(2014-05-09)Heterozygous Alport mutations of type IV collagen genes lead to Benign Familial Hematuria without excessive proteinruia or progression to end stage kidney disease. Heterozygous polymorphisms of the podocin-gene also do not ... -
Einfluss der Kollagenrezeptoren ITGA2 und DDR1 in der Pathogenese von glomerulären Nierenerkrankungen am Doppelknockout-Tiermodell
(2014-05-07)The majority of chronic renal diseases is caused by glomerular defects. In this dissertation therefore the role of collagen – receptors DDR1 and ITGA 2 in the pathogenesis of glomerular defects was investigated. The main ... -
Bestimmung von Prognosemarkern unter nephroprotektiver Therapie mit ACE-Hemmern bei chronischer Nierenfibrose am Beispiel des Alport-Syndroms
(2013-11-26)Firstly described in 1927, Alport syndrome is a progressive hereditary nephropathy. Untreated, it leads to end-stage renal failure and is associated with the symptoms of hematuria and proteinuria. The aim of this work was ... -
Erkennung diagnostischer Frühmarker der Nierenfibrose beim Tiermodell des Alport-Syndroms mittels proteomischer Methoden
(2013-03-05)Alport syndrome is a progressive, hereditary nephropathy which is characterized by typical changes in the basement membrane leading to proteinuria and hematuria. Proteines, which then pass the glomerular filter, occurring ... -
Präemptive Therapie mit Angiotensin-Converting-Enzyme-Inhibitoren verzögert Nierenersatztherapie bei heterozygoten Mutationsträgerinnen mit X-chromosomalem und autosomal-rezessivem Alport-Syndrom
(2013-02-08)The Alport syndrome (AS) is a hereditary chronic kidney disease which is characterized by ultrastructural lesions of the glomerular basement membrane (GBM), hearing loss and ocular changes. The cause of AS are various ... -
Prävention des Nierenversagens und der Nierenfibrose bei hereditären Erkrankungen der glomerulären Basalmembran (Alport-Syndrom) bei COL4A3-Knockout-Mäusen mit dem Reninantagonisten Aliskiren
(2012-05-31)The nephroprotectiv properties of the direct renin inhibitor Aliskiren in homozygote COL4A3 knockout mice were analysed in this paper. Consistent with the human disease Alport Syndrome, the mouse model shows the same ...