Browsing Human- und Zahnmedizin by Advisor "Hahn, Heidi Prof. Dr."
Now showing items 1-6 of 6
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The role of Hedgehog signaling and its interaction with EGFR-pathway in cutaneous squamous cell carcinoma
(2020-07-22)Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer and its incidence is increasing worldwide. This highlights the importance of a better understanding of the molecular mechanisms ... -
Analysen zu Interaktionen zwischen dem Vitamin-D-Rezeptor Signalweg und der Hedgehog Signalkaskade
(2014-03-28)The Hedgehog (Hh) signaling pathway is involved in the development of several tumor entities. The pathway component Patched (Ptch) has been suggested to function as a pump for oxysterols and to secrete a molecule – presumably ... -
Sensitivierung von Sarkomzellen gegenüber Doxorubizin
(2012-04-11)Doxorubicin is one of the most effective cytostatic agents and is widely used in a variety of tumor entities. Despite being one of the drugs of choice in sarcoma treatment, doxorubicin sometimes does not show any ... -
1alpha,25-Dihydroxy-VitaminD3 hemmt das Wachstum von Patched-assoziierten Rhabdomyosarkomen und Basaliomen
(2011-11-17)Activation of the Hedgehog (Hh)-signaling pathway due to deficiency in the Hh receptor Patched1 (Ptch) is the pivotal defect leading to formation of rhabdomyosarcomas (RMS) and basal cell carcinoma (BCC). Recent reports ... -
Untersuchungen zur Rolle von Wnt5a beim Basalzellkarzinom
(2010-07-20)Basal cell carcinoma (BCC) is the most common tumour in humans. In almost all BCC analyzed so far the Hedgehog/Patched (Hh/Ptch) signalling pathway is pathologically activated. In the vast ... -
Der Hedgehog Rezeptor Patched bei der Tumorentstehung und in der Hämatopoese
(2007-02-05)In contrast to homozygous mutations heterozygous germline mutations of the Sonic Hedgehog (Shh) receptor Patched (Ptch) are not lethal and predispose with a high incidence to the formation of basal cell carcinomas ...