Browsing Human- und Zahnmedizin by Advisor "Hufert, Frank Torsten Prof. Dr."
Now showing items 1-8 of 8
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Etablierung eines T7-RNA-Polymerase basierten Systems zur Generierung von virus-like particles (VLPs) des Oropouche-Virusʼ
(2023-02-21)Oropouche illness is caused by the Orthobunyavirus Oropouche and causes a febrile disease among Middle and South America. The symptoms are e. g. fever, headache and myalgia. Due to infections not just among arthropods but ... -
The Inhibition of RNA-Polymerase II-Mediated Expression by the Non-Structural Protein NSs of the Oropouche Virus and Establishing an Oropouche Virus Minireplicon System
(2015-06-02)The OROV is a RNA virus that has a segmented, single stranded genome of negative polarity. It belongs to the Bunyaviridae family. Infection by the OROV causes an acute very debilitating febrile episode. This RNA virus is ... -
Klonierung der Genomsegmente des Oropouche-Virus und Charakterisierung der Interferon-antagonistischen Aktivität des S-Segment-kodierten NSs-Proteins
(2015-01-27)Abstract: Oropouche virus (OROV) is a human-pathogenic member of the genus orthobunyavirus within the family Bunyaviridae. Until now, neither an effective antiviral treatment for the dengue fever-like disease caused by ... -
Charakterisierung der TypI-Interferon-antagonistischen Aktivität der humanpathogenen Orbiviren Tribec-Virus und Kemerovo-Virus
(2015-01-20)Tribec- (TRBV) as well as Kemerovo virus (KEMV) are sheep tick (Ixodes persulcatus and Ixodes ricinus) transmitted Orbiviruses (Reoviridae family). They are under suspicion of causing inflammations of the cerebrospinal ... -
Charakterisierung der durch Tribec-Virus induzierten Hemmung der Interferon-β-Induktion
(2015-01-20)The Tribec-virus belongs to the genus of Orbiviruses and was first isolated from blood samples collected in the Tribec-mountains in Slovakia in 1963. Meanwhile, the Tribec-virus has been found in many other European ... -
The Role of NS3 Helicase Domain in Hepatitis C Virus Particle Assembly
(2013-11-22)Hepatitis C virus non-structural protein 3 (NS3) is a multifunctional protein that obtains serine protease, RNA helicase and NTPase activities. The enzyme is essential for viral RNA replication. Its protease domain cleaves ... -
Inhibition des Interferon-Beta-Systems durch Tribec-Virus
(2013-01-03)The Tribec virus (TRBV) is a tick-transmitted Orbivirus (family Reoviridae) which is suspected to cause neurologic aseptic encephalitis in humans. The activation of the interferon system is the first immune response in ... -
Entwicklung und Optimierung eines Cytometric Bead Arrays zum Nachweis von afrikanischen hämorrhagischen Fieberviren
(2012-04-23)Viral hemorrhagic fevers (VHF) are acute infections with high infectivity and high case fatality rates. In most of the cases an effective vaccination or causal therapy does not exist or their availability is limited. ...