Browsing Human- und Zahnmedizin by Advisor "Kramm, Christof Prof. Dr."
Now showing items 1-8 of 8
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Der Effekt der H3.3K27M-Mutation auf die Antitumorwirkung von Curcumin
(2024-10-14)Diffuse intrinsic pontine glioma (DIPG) are pediatric high-grade glioma (pedHGG) with a median overall survival of 11 months after diagnosis. The aggressiveness of this tumor entity appears to be further increased in the ... -
Vergleich klinischer und epidemiologischer Parameter der primären Gliomatosis cerebri und primär multifokaler hochgradiger Gliome im Kindes- und Jugendalter
(2024-08-26)To date no differentiation is being made between varying growth phenotypes of pediatric high-grade gliomas (pHGG). This thesis compares primary pediatric Gliomatosis cerebri (GC) and primary multifocal/multicentric (PMF) ... -
Konsolidierung oder aktive Tumorverkleinerung: Therapeutische Effizienz einer Erhaltungschemotherapie bei hochgradigen Gliomen des Kindes- und Jugendalters
(2024-07-02)High-grade gliomas of childhood and adolescence (pHGG) constitute a heterogenous group of malignant primary tumours of the central nervous system. The prognosis for the majority of pHGG is poor, with only a few therapeutic ... -
Complementary medicine treatment options for children with diffuse intrinsic pontine gliomas
(2024-04-11)Diffuse intrinsic pontine glioma is a rare but lethal brain tumor with a median survival of eleven months after diagnosis. There has been no significant improvement in survival over the past 50 and more years despite ... -
Einfluss der Expression von Signaltransduktion-, Stammzell- und Zellzyklus-assoziierten Genen auf das Gesamtüberleben von pädiatrischen Glioblastompatienten
(2023-07-31)The Glioblastoma multiforme, as a highly malignant brain tumor, is associated with a very unfavorable prognosis. The median survival time after diagnosis is reported to be nine months to two years, with a 5-year survival ... -
Untersuchung der therapeutischen Wirkmechanismen von Kurkumin in diffus intrinsischen Ponsgliomen in Abhängigkeit vom Mutationsstatus im H3F3A-Histongen (H3.3K27M-Mutation)
(2022-10-17)Diffuse intrinsic pontine glioma (DIPG) are pediatric high grade glioma localized in the brainstem and associated with a fatal prognosis. 85% of all DIPG carry a H3K27M mutation, which leads to epigenetic dysregulation ... -
Epidemiologische und klinische Charakterisierung von Langzeitüberlebenden mit hochgradigem Gliom im Kindes- und Jugendalter
(2021-08-30)Pediatric high-grade gliomas account for 8-12% of primary tumors in the central nervous system during childhood. Currently, the prognosis is still dismal. Only about 10% of patients achieve long-term survival. Therefore, ... -
Therapieeffizienz und -sicherheit der simultanen Radiochemotherapie bei hochgradigen Gliomen des Kindesalters: Vergleich zwischen Temozolomid- und Cisplatin-basierten Chemotherapieregimes
(2021-07-27)A retrospective data analysis of a total of 575 children and adolescents from the HIT-GBM-C / D study and the HIT-HGG 2007 study with highly malignant gliomas was carried out. The two simultaneous chemotherapy regimen were ...