Browsing Human- und Zahnmedizin by Advisor "Maier, Lars S. Prof. Dr."
Now showing items 1-20 of 20
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Akuter ST-Strecken-Hebungsinfarkt (STEMI) bei Patientinnen und Patienten mit zusätzlich chronischem Verschluss in einem Nicht-Infarkt-Gefäß: klinische Relevanz und prognostische Bedeutung
(2018-04-06)The topic of "chronic total coronary occlusion" (CTO) is in focus, as in recent years, techniques have been developed that make it possible to achieve revascularization by percutaneous coronary intervention (PCI) even in ... -
Funktionelle Charakterisierung neu entwickelter SERCA2a-Modulatoren an humanem Myokard und isolierten Herzmuskelzellen der Ratte
(2018-03-12)Decreased expression of cardiac sarcoplasmic calcium ATPase SERCA2a is known to play an important role in the pathogenesis of chronic heart failure. Thus stimulation of SERCA2a attracted increased attention as a promising ... -
Angiotensin II reguliert das Natriumkanal- Öffnungsverhalten über zwei Mechanismen: IP3-Rezeptoren aktivieren die CaMKII und ROS die PKA
(2017-09-19)Background: In heart failure (HF) disturbed CaMKII-dependent sodium current (INa) and sodium channel gating leads to arrhythmias and contractile dysfunction. Enhanced Angiotensin II (Ang II) signaling has been implicated ... -
Die Untersuchung der putativen Mechanosensor-Komponenten Melusin und T cap und deren Einfluss auf die elektromechanische Kopplung im Kardiomyozyten bei adaptiver und maladaptiver Hypertrophie
(2017-09-06)An important research topic is the analysis of hypertrophic signals in cardiomyocytes leading to heart failure. There are suspected intracellular mechanosensors in the signal transduction. The proteins Melusin and T-cap ... -
Einfluss der Ca2+/Calmodulin-abhängigen Proteinkinase II delta auf den L-Typ Ca2+-Strom -Untersuchungen anhand eines genetischen Knock-outs im Mausmodell
(2016-12-20)Ca2+/calmodulin-dependent kinase II delta plays an important role in heart failure as activity and expression of the kinase are higher in myocytes of failing hearts. In this dissertation transverse aortic constriction led ... -
Der Einfluss des AT2-interacting Protein 1 (ATIP1) auf die Kontraktilität und den Kalziumstoffwechsel von ventrikulären Herzmuskelzellen
(2016-12-12)In the context of this work, ATIP1 knockout mice demonstrated for the first time that both the AT2 receptor and the AT2-interacting protein 1 (ATIP1), which interacts with this receptor, have a functional influence on ... -
Angiotensin II induziert Nox 2 -abhängig Arrhythmien in ventrikulären Kardiomyozyten der Maus
(2015-10-28)Heart failure and cardiac arrhythmias are prevalent diseases which occure mainly in older patients. With regard to the demographic change their importance will even increase in the nexts decades. Mechanisms of heart failure ... -
Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen
(2015-10-28)The effects of the novel CaMKII inhibitor on Ca2+ handling and EC coupling of isolated murine cardiomyocites were evaluated using epifluorescence and confocal microscopy. SMP-114 warranted a significant reduction in diastolic ... -
Funktionelle Charakterisierung der Kalzium/Calmodulin-abhängigen Proteinkinase-II-δ (CaMKIIδ)-Knockout-Maus
(2013-12-03)CaMKII, the Ca2+/Calmodulin-dependent protein kinase-II, is a multifunctional serine/threonine protein kinase that is a central regulator of cardiomyocyte excitation-contraction-coupling. Several isoforms exist. In the ... -
Evaluation eines neuartigen kapazitiven EKG-Systems bei Patienten mit akutem ST-Hebungs-Myokardinfarkt
(2013-12-02)OBJECTIVE The ECG plays a central role in the rapid diagnosis of acute myocardial infarctions (MI). In haemodynamically instable patients, adhesion of electrodes sometimes is difficult and assessing ECGs through layers ... -
Transport- und Behandlungszeiten im Herzinfarktnetzwerk Göttingen
(2013-11-26)Acute myocardial infarction is one of the leading causes of death worldwide. Evidence shows that prompt percutaneous coronary intervention (PCI) reduces mortality and improves outcome in patients with ST-segment-elevation ... -
Die Effekte der Ca2+-Calmodulin-abhängigen Proteinkinase II (CaMKII) auf die Aktionspotential-morphologie bei mechanischer Last
(2013-10-25)The Calcium2+/Calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase and acts as a key regulator of excitation contraction coupling in cardiac myocytes. There are several ... -
Die Bedeutung der δ-Isoform der Kalzium-Calmodulin-abhängigen Proteinkinase II (CaMKII) für die Azidose bei isolierten Kardiomyozyten
(2013-10-23)Objective: CaMKII-dependent Thr-17 phosphorylation of PLB leading to higher SERCA activity has been suggested to maintain or even partially recover fractional shortening (FS) and intracellular Ca transient amplitude (ΔF/F0) ... -
Die Bedeutung der Kalzium/Calmodulin-abhängigen Proteinkinase II für den gestörten Kalziumstoffwechsel der isolierten Rattenherzmuskelzelle unter Doxorubicinbehandlung
(2013-07-08)Doxorubicin (DOX), a member of the anthracycline family, is one of the oldest and most commonly used chemotherapeutic agents. Despite its therapeutic benefits, its cardiotoxic potential, resulting in severe cardiac damage, ... -
Die Wirkung ionisierender Strahlung auf die elektromechanische Kopplung und den intrazellulären Ca2+-Haushalt in isolierten Herzmuskelzellen
(2012-07-20)Introduction: The radiooncological treatment procedure of tumors of the thorax (e.g. hodgdkin-lymphom, lung, mamma, oesophageal and gastric carcinoma) can in addition to the tumor expose the heart to ionizing radiation. ... -
Die Rolle des späten Natrium-Stroms bei der Kalzium-Calmodulin-abhängigen ProteinkinaseIIδC (CaMKIIδC)-induzierten Herzinsuffizienz und beim chronischen Vorhofflimmern
(2012-06-21)Ranolazine is a drug that was introduced for antianginal therapy in Germany in 2008. Its effects are explained by inhibition of the so called „late Na+-current“ in the cardiomyocyte. Contrary to the „fast Na+-current“, ... -
Inhibtion der Ca<sup>2+</sup>/Calmodulin-abhängigen Proteinkinase (CaMKII) verbessert die Kontratilität von terminal insuffizientem Myokard des Menschen
(2011-12-12)Heart failure is known to be associated with increased Ca2+/calmodulin-dependent protein kinase (CaMKII) expression and activity. But the functional effects of CaMKII and detailed expression ... -
Einfluss der Calstabin2-Mutante FKBP12.6D37S in gesunden Mauskardiomyozyten und in einem transgenen Herzinsuffizienzmodell, das die Kalzium/Calmodulin-abhängige Proteinkinase IIδc überexprimiert
(2011-08-24)In heart failure (HF) calcium/calmodulin-dependent protein kinase IIdc (CaMKIIdc) and protein kinase A (PKA) are activated and promote diastolic sarcoplasmic reticulum (SR) calcium (Ca) ... -
Einfluss des α1(I)-Kollagens auf die Aktionspotentiale von frühen aus embryonalen Stammzellen differenzierten Kardiomyozyten
(2011-07-04)Type-I collagen is the main component of the cardiac extracellular matrix (ECM). Knockout (KO) of α1(I)-collagen is embryonically lethal. In-vitro-differentiation of cardiomyocytes from ... -
Die Hemmung der PI3K verstärkt die Kontraktilität in alpha1-adrenerg stimuliertem Myokard
(2010-11-18)Recent studies have demonstrated that phosphoinositide 3-kinases (PI3Ks) play a fundamental role in regulating myocardial contractility. However, even though a1-adrenergic receptor stimulation ...