Blättern Human- und Zahnmedizin nach "Oetjen, Elke Prof. Dr." Betreuer
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Hemmung des β-zellspezifischen Transkriptionsfaktors MafA durch die Dual Leucine-Zipper-Kinase (DLK)
(2013-05-27)Pathophysiology of diabetes mellitus type 2 is characterized through progressive loss of functional β-cell-mass with inadequate insulin biosynthesis and insulin secretion. Insulin gene transcription is an important β-cell ... -
Regulation der Dual-leucine-zipper-kinase (DLK) durch "prädiabetische" Signale in endothelialen HUVEC-Zellen und die Bedeutung der DLK für die Angiogenese in einem Mausmodell
(2013-11-21)Diabetes mellitus and its serious effects on veins and arterys are a major problem in todays society. Important aspects of the disease are microangiopathy and macroangiopathy, which may lead to stroke or death. It is ... -
Wirkung der proinflammatorischen Zytokine TNF-Alpha und IL-1Beta auf die CREB abhängige Gentranskription und das Zellüberleben in Abhängigkeit von der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
(2014-06-23)In the year 2008 worldwide 347 million people were affected by diabetes and the incidence was still increasing. The major subtypes are type 2 diabetes (90%) and type 1 diabetes (10%) (Danaei et al. 2011). Both types of ...