Blättern Human- und Zahnmedizin nach "Simons, Mikael Prof. Dr." Betreuer
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Konditionale Inaktivierung von Pten in einem neuen Mausmodell für tomaculöse Neuropathien
(2017-01-30)Schwann cells in the peripheral nervous system form the myelin sheath by wrapping multiple membrane layers around axons with a diameter greater than 1 μm. Such ensheathment of the axon is considered an important prerequisite ... -
Roles of bHLH Transcription Factors Neurod1, Neurod2 and Neurod6 in Cerebral Cortex Development and Commissure Formation.
(2016-04-07)Basic helix-loop-helix (bHLH) proteins constitute a diverse group of evolutionary well-conserved transcription factors. Many transactivating bHLH proteins follow cell type- or tissue-specific expression patterns and act ... -
Die Rolle der Beta-Sekretase bei der Myelinisierung im Zentralen Nervensystem
(2014-04-15)BACE1, the beta-secretase, plays a significant role in the formation of amyloid, a histopathological hallmark of Alzheimer's Disease. The physiological function of BACE1 remains unclear. Recent studies showed a role in ... -
Untersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodell
(2013-01-24)During the process of myelination in vertebrates axons are spirally ensheathed by the oligodendroglial plasma membrane. This ensheathment consists of a highly specialized membrane with a distinct protein and especially ... -
Evaluation des Patientenbetreuungsprogramms BETAPLUS® zur begleitenden Unterstützung der Therapie mit Betaferon® (Interferon beta-1b)
(2012-08-13)The neurodegenerative autoimmune disease multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). When myelin sheaths of the nerve axons are offended, multiple demyelinating ... -
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
(2011-01-27)Oligodendrocytes are the myelin forming cells of the central nervous system. These cells synthesize vast amounts of membrane during the active phase of myelination. In addition, membrane ... -
Charakterisierung der subzellulären Lokalisation von Myelinproteinen in der Shiverer-Maus.
(2010-07-05)As dysmyelinating diseases in humans and animals show, myelin as isolation sheath of nerve fibres has essential functions. It is a membrane of very specific composition the components of ...