Blättern Human- und Zahnmedizin nach "Ströbel, Philipp Prof. Dr." Betreuer
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Fluoreszenz-in-situ-Hybridisierung und funktionelle Analyse der KMT2A-MAML2 Translokation in epithelialen Thymusneoplasien und den humanen Zelllinien 1889c und MP-57
(2024-04-25)Thymoma and thymic carcinoma are very rare epithelial neoplasms of the thymus. Little is known about the pathogenesis of these tumors. Targeted therapeutic approaches have hardly been established to date, and the recurrence ... -
Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinoma
(2023-07-17)With nearly 40 %, pulmonary adenocarcinomas are the main subgroup of non-small cell lung cancers. Activating KRAS mutations occur in about 30 % of pulmonary adenocarcinoma cases and the discovery of the G12C KRAS ... -
Vergleichende immunhistochemische Analyse onkogener Signalwegssignaturen in Lymphomen
(2023-03-03)B-cell lymphomas are a group of malign neoplasms derived from lymphoid B-cells. The targeted therapy of B-cell lymphomas includes the inhibition of oncogene signaling which is mediated via the B-cell receptor (BCR). However, ... -
Charakterisierung der Immunantwort auf Sentinel-Lymphknoten-Metastasen beim malignen Melanom
(2023-02-23)Malignant melanoma is an immunogenic tumor that in most cases triggers an immunological defense reaction. In order to better understand the immunological processes, metastases of melanoma found in sentinel lymph nodes, as ... -
Die Funktionsanalyse der Caspase-3 und des Yes-associated Proteins in epithelialen Thymusneoplasien
(2023-02-07)Thymic neoplasms are very rare neoplasms in the thymus that arise from the epithelium of the thymus, located in the mediastinum. Little is known about their etiopathogenesis, but they represent the adult tumor entity with ... -
Differentielle Methylierung von H3K27 in EZH2 positiven large cell neuroendokrinen Tumoren des Thymus
(2023-02-02)Neuroendocrine thymic tumors represent only 0.4% of all neuroendocrine tumors and are thus very rare. Four subtypes are classified by the WHO. A high-grade subtype is the large cell neuroendocrine carcinoma, which is ... -
Proteomische Analyse von neuroendokrinen Tumoren des Thymus und der Lunge
(2022-12-12)Neuroendocrine tumours of the thymus are very rare neoplasms. The closest related group of tumours are neuroendocrine tumours of the lung. Both are classified using the same criteria into four subtypes: typical carcinoid, ... -
Quantifizierung von Entzündungszellen („Immuno-Score“) im Knochenmark von Patienten mit myelodysplastischem Syndrom (MDS)
(2022-10-25)MDS is a complex disease with its challenging diagnosis and prognosis determination. The prognosis of patients with MDS is very heterogeneous and therefore prognostic systems have to be developed that allow risk stratification ... -
Proteomische Analyse von Plattenepithelkarzinomen des Kopf-Hals-Bereichs und Plattenepithelkarzinomen der Lunge
(2022-07-26)Patients with squamous cell carcinoma of the head and neck may develop both lung metastasis and metachronous squamous cell carcinoma of the lung due to shared risk factors such as tobacco smoke. Distinguishing between these ... -
Überwindung der Chemoresistenz bei malignen Thymomen und Thymuskarzinomen
(2022-07-18)This work focused on four proteins that have been prominent in previous studies of resistance in tumor therapy. FoxM1 and cyclin B1 are cell cycle regulatory proteins that promote the transition into mitosis. FoxM1 induces ... -
Eine Untersuchung der Bedeutung des Apoptose-induzierenden Faktors am podozytären Zelltod
(2022-06-17)In this work, the involvement of apoptosis-inducing factor (AIF) in podocyte cell death was investigated in vitro using an established podocyte cell line. For this purpose, a model was used in which the three different ... -
Comparative Morphologic and Molecular Classification of Neuroendocrine Tumors of the Thymus in Humans
(2021-04-30)Neuroendocrine tumors (NET) of the thymus are rare neoplasms that share many similarities with their pulmonary counterpart. The WHO 2015 classification of thymic and pulmonary NET divides tumors into typical and atypical ... -
Optimierte expressionsbasierte Mikrodissektion an Formalin-fixiertem Gewebe des Adenokarzinoms der Lunge
(2021-04-13)In precision medicine of tumors, the analysis of specific DNA alterations is crucial for targeted therapy. Lung cancer represents a prototypical example and is also one of the leading causes of cancer-related deaths ... -
One-carbon metabolism in lung cancer
(2020-10-26)One-carbon metabolism (1CM) plays a central role in cell proliferation and an elevated activity is accounted for the progression of several cancer types. Increased 1CM is a known risk factor for lung cancer and the anti-folate ... -
Einfluss des Aktin-bindenden Proteins Synaptopodin-1 auf die Prognose des Pankreaskarzinoms
(2019-01-07)Adenocarcinomas of the pancreas are among the four most common causes of cancer-related mortality worldwide and have an increasing incidence. The prognosis for pancreatic carcinoma is poor with an average five-year survival ... -
Histomorphologische Kriterien für zytogenetisches Risiko beim myelodysplastischen Syndrom
(2018-05-14)Introduction: Myelodysplastic syndrome (MDS) is a complex, heterogenous disease. Making a diagnosis and determining the prognosis poses a challenge to the hematopathologist in the clinical setting. This dissertation ...