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Speziesunterschiede im organischen Kationentransporter OCT1: Vergleich der Effekte der Aminosäuren F159, W217 und D474 in OCT1 des Menschen, der Maus und der Ratte
(2020-11-26)OCT1 is an integral membrane transporter that is able to transport certain substrates with cationic components in the molecular structure across the plasma membrane of cells. This transporter is important for the human ... -
Comparative Analysis of Opioids as Substrates and Inhibitors of the Human Organic Cation Transporter 1 (OCT1)
(2020-08-03)The organic cation transporter 1 (OCT1) is primarily located in the sinusoidal membranes of hepatocytes and mediates phase 0 biotransformation of xenobiotics, including weak basic and cationic drugs. Variations in SLC22A1, ... -
Erweiterte Charakterisierung substratspezifischer Effekte genetischer Polymorphismen im organischen Kationentransporter OCT1
(2019-10-09)The human organic cation transporter 1 (OCT1) mediating the hepatic uptake of drugs and cationic substances shows high genetic variability. About 9% of the population are carriers of two inactive OCT1 alleles (poor OCT1 ... -
Charakterisierung der weltweiten genetischen Variabilität des Transporters für organische Kationen OCT1
(2017-08-09)The organic cation transporter OCT1 is one of the highest expressed membrane transporters in hepatocytes and mediates the uptake of cationic and weak basic drugs and xenobiotics. The OCT1 gene SLC22A1 is highly polymorphic ...