Browsing Human- und Zahnmedizin by Advisor "Weber, Martin Prof. Dr."
Now showing items 1-6 of 6
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Impact of the sphingosine-1-phosphate receptor modulator siponimod on functional phenotypes of microglia
(2024-11-26)Over the last decades the number of drugs for the therapy of relapsing remitting multiple sclerosis (RRMS) increased significantly, whereas various approaches to develop an efficient therapy for secondary progressive ... -
The role of regulatory B cell properties in multiple sclerosis - future therapeutic implications
(2024-09-23)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which affects 2.8 million people worldwide. Most likely, B cells play an important role in its immunopathogenesis, however, they also ... -
The effect of Natalizumab on functional properties of monocytes in patients with Multiple Sclerosis
(2024-01-12)Natalizumab (NTZ), a monoclonal antibody against very late antigen-4 (VLA-4), is one of the most efficient therapies to prevent acute relapses in multiple sclerosis (MS). Since VLA-4 is a vital adhesion molecule for ... -
The effect of glatiramer acetate on functional properties of B lymphocytes in patients with MS
(2021-11-29)Objective: We examined the effect of glatiramer acetate (GA) on B-cell maturation, differentiation, and antigen presentation in MS patients. Methods: A cross-sectional study of blood samples from 20 GA-treated and 18 ... -
Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis
(2021-08-10)B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis (MS). However, little is known about the maturation/activation stage of the returning B cell population after treatment ... -
The effect of dimethyl fumarate on phenotype and function of B lymphocytes in MS patients
(2021-04-09)Although the oral agent DMF was approved for the treatment of RRMS in 2014 and demonstrably reduces relapse rates and disability progression, its effect on B cells, which are now thought to be major contributors to disease ...