Browsing Human- und Zahnmedizin by Advisor "Zimmermann, Wolfram-Hubertus Prof. Dr."
Now showing items 1-5 of 5
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Über die Herstellung von humanem Makro-Herzgewebe zur Therapie der Herzinsuffizienz
(2022-10-27)The prognosis of chronic heart failure remains unfavourable despite optimal therapy. Cardiac tissue engineering is seen as a promising approach to cardiac heart repair. The aim of this work was to investigate whether human ... -
Development of a Novel Fluorescence Indicator System for the Characterization of Sarcomere Organization an Function in Human Cardiomyocytes
(2022-03-16)In this work, we describe a novel fluorescence indicator system for the in-vitro characterization of human stem cell-derived cardiomyocytes (hPSC-CM). We hypothesized that a) Z-lines in hPSC-CM can be reliably labeled via ... -
Über die Differenzierung und Charakterisierung von Kardiomyozyten aus induzierten pluripotenten Stammzellen aus Rhesusmakaken in 2D- und 3D-Kulturen
(2021-11-03)Introduction: Cardiovascular diseases play a leading role in the western industrial nations in terms of mortality, morbidity and economic costs. At the same time, the heart transplant is the only causal therapy for heart ... -
Über die Rolle der induzierbaren NO-Synthase für die Statinmyotoxizität in einem In vitro-Skelettmuskelmodell
(2017-03-03)Statins are an often prescribed drug against hyperlipidemia and as prophylaxis of cardiovascular diseases. They work as an inhibition of the cholesterol synthesis by inhibiting the enzyme HMG-CoA-reductase. As a common ... -
Über die Auswirkung mechanische Last auf die Entwicklung von künstlichem Herzgewebe
(2014-11-28)The production of EHM with undifferentiated murine embryonic stem cells was improved and stabilized by multiple factors (Matrigel-free culture, supplementation of ascorbic acid, culture conditions). Cardiogenesis of ...