Browsing Human- und Zahnmedizin by Referee "Bastians, Holger Prof. Dr."
Now showing items 1-16 of 16
-
Der Effekt der H3.3K27M-Mutation auf die Antitumorwirkung von Curcumin
(2024-10-14)Diffuse intrinsic pontine glioma (DIPG) are pediatric high-grade glioma (pedHGG) with a median overall survival of 11 months after diagnosis. The aggressiveness of this tumor entity appears to be further increased in the ... -
Einfluss medikamentöser Inhibition des Phosphoinositid-3-Kinase Signalwegs auf die Regulation mitochondrialer Apoptose in peripheren T-Zell Lymphomen
(2024-09-13)Peripheral T-cell lymphomas are a group of genetically heterogeneous and aggressive diseases. Poor tumor response to CHOP-based chemotherapy protocols and a lack of treatment options in relapses lead to a generally poor ... -
Zur Interaktion von MYC mit TPX2 in der Mitose
(2024-07-15)The transcription factor MYC is one of the most frequently deregulated proteins in oncological diseases; it occupies a central position in malignant transformation due to its essential role in the regulation of proliferation. ... -
Die Rolle des Transkriptionsfaktors LEF-1 im Hodgkin-Lymphom
(2019-07-26)Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas. The malignant cells in cHL form only a small part of the tumour, whereas the majority consists of a reactive infiltrate of stromal cells and ... -
Evaluation von Antagonisten des Wnt-3a-Signalwegs in diffusen großzelligen B-Zell-Lymphomen
(2018-11-26)Deregulated activation of Wnt-3a-signaling is a mechanism of intratumoral homeostasis in diffuse large B cell lymphoma (DLBCL). The topic of this study was to evaluate antagonists of this signal pathway for the first time ... -
GPR 30 - Zielgerichtete Therapie triple-negativer Mammakarzinome durch Bindung des östrogensensitiven Rezeptors GPR 30
(2017-11-27)When considering the whole entity of malignant breast tumors the TNBC (triple-negative breast cancer) shows due to its lack of receptors for estrogen, progesterone and missing susceptibility to the monoclonal antibody ... -
The role of chromosomal instability in therapy response of colorectal cancer
(2017-11-09)Chromosomal instability (CIN) represents a major hallmark of cancer and is defined as the perpetual gain or loss of whole chromosomes during mitotic cell division. It is thought that CIN can drive tumor cell evolution by ... -
Wnt-Signalwegsanalysen während der Metastasierung von Mamma-Karzinomen
(2016-10-26)Wnt signaling plays a crucial role in developmental processes and diseases such as cancer. We recently revealed activation of β-Catenin independent Wnt signaling in cerebral metastases of breast cancer patients (Klemm F ... -
Der natürliche Wnt-Antagonist SFRP4 in der Wachstumsregulation von diffusen großzelligen B-Zell-Lymphomen
(2016-04-04)The heterogeneous biology of diffuse large B-cell lymphomas (DLBCL) and the resulting differences in treatment response and prognosis represent a significant problem in the current treatment of DLBCL. Anomalies in canonical ... -
Die Expression von SRC vor und nach neoadjuvanter Radiochemotherapie im lokal fortgeschrittenen Rektumkarzinom cUICC II/III.
(2016-01-12)Purpose: SRC, one of the oldest proto-oncogenes, is encoding for the tyrosine kinase of the same name. The protein, which is localized in the cytosol as well as in the cell membrane, is involved in cell proliferation and ... -
Expressionshemmung von MCM3 in Glioblastomen durch RNA-Interferenz
(2015-03-06)This work shows effects of specific suppression of MCM3-protein, which is upregulated in human glioblastoma cells (U87MG), by using RNAi. The effects on metabolic activity, cell viability, proliferation, cell cycle and ... -
Die anti-tumorale Wirkung des neuen Phosphoinositid-3-Kinase-Inhibitors BAY 80-6946 auf humane Myelom-Zellen
(2015-01-12)Overcoming drug resistance in the bone marrow microenvironment is an unresolved challenge in therapy of multiple myeloma. Despite numerous therapeutic approaches with new agents targeting the bone marrow microenvironment ... -
Die Wirkung des Histondeacetylase-Inhibitors Valproinsäure auf Keimzelltumoren des Hodens
(2014-07-30)Testicular germ cell tumours (TGCT) are the most common malignancy in young men. They are clinically and histologically subdivided in seminomas and non-seminomas. In 2001 valproic acid (VPA) has been described as an ... -
GnRH-Rezeptor-vermittelte Therapie des triple-negativen Mammakarzinoms
(2013-08-16)Triple-negative breast cancer does not express estrogen and progesterone receptors and there is no overexpression/amplification of the HER2-neu gene. Therefore this subtype of breast cancer lacks the benefits of specific ... -
In-vitro- und in-vivo-Hemmung des AKT-Signalweges in Melanomzellen durch einen neuen kleinmolekularen Inhibitor
(2013-01-28)Constitutive activated signaling pathways are responsible for malignant changes in melanocytes that lead to melanoma. PI3Kinase-AKT-pathway and MAPK-ERK-pathway are known to play a significant role within the melanoma ... -
Etablierung und Validierung der RNA-Interferenzmethode am Beispiel Apoptose-relevanter Gene
(2012-07-05)Specific inhibition of gene expression is becoming an increasingly important method for experimental strategies to influence tumor growth on a molecular level. In this work, we investigated the role of individual molecules ...