Browsing Human- und Zahnmedizin by Referee "Burckhardt, Birgitta-C. Prof. Dr."
Now showing items 1-9 of 9
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Einfluss des extrazellulären pH-Werts auf den Transport von para-Aminohippurat über den organischen Anionentransporter 1
(2015-02-10)Organic anion transporter 1 (OAT1) is one of the transporters responsible for renal elimination of organic anions. In the present study, the influence of extracellular pH on the transport-activity of OAT1 was examined using ... -
Regulation des Sulfat-Anionen-Transporters-1, sat-1, in Caco2-Zellen durch Oxalat und dessen Vorstufen
(2014-11-25)Nephrolithiasis is a major health problem caused by hyperoxaluria. The sulfate anion transporter-1 which transports sulfate and oxalate might be involved in the development of hyperoxaluria, so further information concerning ... -
Strukturwirkungsbeziehungen am Na+-abhängigen Dicarboxylat-Cotransporter 3(hNaDC3)
(2013-06-24)This experimental study investigates the interactions between various substances (succinate, glutamate, glutathion, glycine, cysteine, fumarate, N-oxalyl glycine, glycylglycine) and the sodium-dicarboxylate cotransporter-3 ... -
Untersuchungen zur Chloridabhängigkeit des Sulfat-Anionen-Transporters 1
(2013-04-23)The sulfate-anion-transporter-1 is localized in the basolateral membrane of the proximal tubular cells and the sinusoidal membrane of hepatocytes. Earlier studies showed species differences with respect to chloride transport ... -
Interaktionen von Diuretika mit dem humanen Natrium-abhängigen Dikarboxylat-Transporter (hNaDC-3)
(2012-02-15)Due to their high protein binding, diuretics are tubular secreted. This process takes place in the proximal tubular cells of the kidney via the organic anion transporters hOAT1 and hOAT3, ... -
Die Expression von Sulfattransportern als Funktion einer fortschreitenden Nierenfibrose am Modell der Alport-Maus
(2012-01-13)The system of sulfate metabolism and the expression of sulfate transporters in kidney and liver tissue are influenced by various parameters. The focus of this thesis lies on the sulfate ... -
Einfluss von Transforming Growth Factor - beta 1 (TGF-β1) und Hypoxie auf die Expression von Sulfattransportern (SAT-1 und NaSi-1) in den humanen renalen Zelllinien TK173 und TK188
(2011-08-01)Renal fibrosis as a consequence of a variety of primary diseases such as diabetes mellitus and arterial hypertonus is based on a production of extracellular matrix (ECM) by fibroblasts. ... -
Elektrophysiologische Charakterisierung eines Betain/GABA-Transporters
(2011-07-18)Background: The cells in the renal medulla are exposed to high osmolarities during urine concentration. Betaine and g-aminobutyric acid (GABA) are important osmolytes which prevent cell ... -
Elektrophysiologische Untersuchungen von Transporteigenschaften des Natrium-Dikarboxylat-Kotransporters aus der Flunderniere
(2008-10-02)The goal of this thesis was a deeper electro-physiological characterization of the Sodium-Dicarboxylate-Cotransporter from the kidney of the winterflounder (fNaC3). Both the wild type and ...