Dokumente Human- und Zahnmedizin nach Gutachter "Dresbach, Thomas Prof. Dr."
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Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ... -
Cytoskeletal assembly in axonal outgrowth and regeneration analyzed using STED microscopy
(2023-11-17)The cytoskeleton is essential for axon outgrowth and regeneration. It must be able to tolerate mechanical force and torsion while also allowing for adaptation and response to trauma or injury, such as axonal lesions. Recent ... -
Der Einfluss von Δ9-Tetrahydrocannabinol und Cannabidiol auf die Pathologie des Morbus Alzheimer im Tg4-42hom-Mausmodell
(2023-09-29)This thesis evaluates the histopathological effects of a long-term application of Cannabidiol and delta-Tetrahydrocannabiol in a mouse model of the sporadic Alzheimer`s disease in a preventive and therapeutic approach ... -
Der Einfluss von Cannabidiol auf die Alzheimer Pathologie im 5xFAD Mausmodell in einem präventiven Behandlungsansatz
(2023-08-22)This work examines the neurohistological effects of chronic treatment with cannabidiol on pathologies typical of Alzheimer's disease in the cortex and hippocampus of the 5xFAD mouse model. These include accumulation of ... -
Quantitative Analysen hippocampaler Interneuronen in zwei transgenen Alzheimer Mausmodellen
(2022-09-20)Characteristic pathologies of Alzheimer's disease are extracellular amyloid plaques, early intracellular Aβ accumulation and marked neuronal loss. The Tg4-42 mouse model expresses the Aβ4-42 peptide, which accumulates ... -
Cannabinoid-basierte Therapie in einem Modell für die sporadische Alzheimer-Erkrankung
(2022-09-14)The endocannabinoid system (ECS) is involved in several metabolic processes of the human body and has among others a neuroprotective and anti-inflammatory effect on the central nervous system. Tetrahydrocannabinol (THC) ... -
Cooperative Action of Neuroligins and Brain-Derived Neurotrophic Factor Mediates Presynaptic Maturation
(2022-09-02)Mutations in genes for postsynaptic cell adhesion molecules called neuroligins – in particular the isoforms neuroligin-1, neuroligin-3, and neuroligin-4 – have been implicated in autism spectrum disorders. In cultured ... -
Der Einfluss rekombinanter Neuroligine auf die neuronale Reifung
(2022-06-21)Neuroligins are a group of postsynaptic adhesion molecules associated with formation, maturation and function of neuronal synapses. Additionally, some isoforms have been connected to autism spectrum disorders. Neuroligin ... -
Therapeutischer Nutzen einer stabilisierten systemischen Redoxbalance im Rett-Syndrom: Bewertung plethysmographischer und elektrophysiologischer Parameter
(2022-03-08)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene. The MECP2 gene encodes MeCP2 (methyl-CpG-binding protein 2), which acts as a transcriptional regulator and can stimulate and ... -
Der Einfluss von Lithium auf die Myelinisierung im peripheren Nervensystem
(2022-01-27)Lithium salts are used in clinical practice for the prophylaxis of bipolar affective disorder and for the treatment of major depression. In addition, there are many experimental approaches for the treatment of cognitive ... -
Der Einfluss von (-)-Δ9-trans- Tetrahydrocannabinol und Cannabidiol auf die Alzheimer-Pathologie im 5XFAD-Mausmodell
(2021-12-06)The aim of the present work was to investigate the therapeutic influence of THC and CBD regarding behavioral changes, amyloid plaque pathology, neuroinflammation and CB1 receptor expression using the common Alzheimer’s ... -
Evaluierung einer oralen Antioxidantien-Therapie in einem Mausmodell für das Rett-Syndrom
(2021-09-06)Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by spontaneous mutations in the X-chromosomal gene MECP2 encoding methyl-CpG binding protein 2 (MeCP2). Affecting almost exclusively females, it causes ... -
Der Einfluss von humanem Wildtyp-Alpha-Synuclein und seinen Mutationen A30P und A53T auf das Neuritenwachstum primärer dopaminerger Mittelhirnneurone der Ratte
(2021-01-11)Parkinson´s disease (PD) is the second most common neurodegenerative disease with increasing prevalence worldwide. Despite extensive research, current treatments of PD remain purely symptomatic while neuroprotective and ... -
Der Einfluss von humanem α-Synuclein-Wildtyp und der Mutanten A30P und A53T auf die Autophagie und den Transport synaptischer Vesikel in primären Mittelhirnneuronen der Ratte
(2020-09-29)Despite the expanding pathological understanding of Parkinson´s disease (PD) the relevant pathomechanisms are still not completely understood. Previous evidence suggests that disturbed cellular proteindegradation (autophagy) ... -
Analyse von zehn synaptischen Proteinen in Ratten-Hirnschnitten mittels STED-Mikroskopie zeigt geringfügige Unterschiede zwischen Hirnarealen in Bezug auf Quantität und Lokalisation
(2020-06-19)The role of the synapse as a central element of neuron function has been discussed widely over the years. Likewise, differences between different neurons regarding their anatomy, function (motor, sensor, association), ... -
Therapiemöglichkeiten der Alzheimer-Krankheit durch passive Immunisierung mit dem NT4X-Antikörper im Tg4-42hom-Mausmodell
(2017-07-05)Aβ4-42 is one of the major variants of beta-amyloid (Aβ) in the Alzheimer brain and one of the earliest to appear in the development of the disease. It shows an increased aggregation tendency and toxicity. Furthermore it ... -
Die Wirkung von postnataler Hypoxie auf die neuronale Zellproliferation im Rattenhirn und ihre Relevanz für die Schizophrenie
(2016-02-24)Neonatal hypoxia as a complication of pregnancy and birth is the most important predisposing environmental factor in the pathophysiology of schizophrenia. It leads to damage to the brain and the disruption of brain ... -
Untersuchung von Proteomveränderungen im Synaptosom von Patienten mit sporadischer Creutzfeldt-Jakob-Krankheit
(2013-03-07)Sporadic Creutzfeldt-Jakob disease (sCJD) is characterized by wide clinical and pathological variability. This heterogeneity might be caused by the involvement of different molecular pathways depending on the prion agent ... -
Additiver Mikroglia-vermittelter Neuronenschaden durch β-Amyloid und bakterielle Toll-like-Rezeptor-Agonisten in primären murinen Mikroglia-Neuronen-Kokulturen. Entwicklung eines Auswertungsalgorithmus zur Quantifizierung des Neuronenschadens mit Hilfe einer Software zur objektorientierten Bildanalyse
(2012-06-06)Activated microglia is considered to be involved in the progression of Alzheimer´s dementia (AD). We investigated the effect of Aβ40 and exogenous agonists of TLR1/2 [Pam3CSK4] and TLR4 [LPS] on neurons in primary ... -
Untersuchungen zu synaptischen Proteinen in einem Tiermodell für die Alzheimer-Krankheit
(2011-07-05)Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common cause of dementia. Extracellular senile plaques, neurofibrillary tangles as well as axonal and synaptic ...