Browsing Human- und Zahnmedizin by Referee "Dresbach, Thomas Prof. Dr."
Now showing items 1-20 of 26
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Einfluss von Citalopram auf die Alzheimer-Pathologie im Tg4-42-Mausmodell
(2025-05-12)Alzheimer’s disease is the most common form of dementia and currently remains without a curative or preventive treatment. Characteristic pathological features include amyloid-β (Aβ-) accumulation, neuroinflammation, synaptic ... -
Die Rolle glyzinerger Neurone und des Asc-1 Transporters bei der Modulation der glutamatergen, NMDA-Rezeptor vermittelten synaptischen Transmission am Nucleus nervi hypoglossi
(2025-01-09)The aim of this thesis was to investigate the role and function of glycinergic neurons and the Asc-1 transporter in the modulation of glutamatergic NMDA receptor-mediated synaptic transmission in motoneurons of the hypoglossal ... -
Charakterisierung der Synapsen-spezifischen Verteilung des Proteins Mover während der Differenzierung neuronaler Primärkulturen
(2024-12-13)The protein Mover was identified as a binding partner of the presynaptic scaffolding protein Bassoon using a yeast two-hybrid system. Biochemical studies have shown that Mover is associated with synaptic vesicles. ... -
Auswirkungen von Cannabidiol (CBD) auf das Gedächtnis, Angst- und Lernverhalten sowie die Alzheimer Pathologie in weiblichen 5xFAD Mäusen
(2024-11-15)In this study, the influence of the non-psychoactive cannabinoid cannabidiol (CBD) on amyloid pathology, neuroinflammation, as well as cognitive and anxiety-related behavioral changes associated with Alzheimer's disease ... -
Die Auswirkungen von ∆9-Tetrahydrocannabinol auf Gedächtnisstörungen und die Aβ-Pathologie im 5xFAD-Mausmodell
(2024-09-13)Alzheimer´s disease (AD) is the leading cause for dementia worldwide. It is characterized by a progredient cognitive decline, memory deficits and deposits of proteins called Amyloid beta (Aβ). Familial AD is characterized ... -
Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ... -
Cytoskeletal assembly in axonal outgrowth and regeneration analyzed using STED microscopy
(2023-11-17)The cytoskeleton is essential for axon outgrowth and regeneration. It must be able to tolerate mechanical force and torsion while also allowing for adaptation and response to trauma or injury, such as axonal lesions. Recent ... -
Der Einfluss von Δ9-Tetrahydrocannabinol und Cannabidiol auf die Pathologie des Morbus Alzheimer im Tg4-42hom-Mausmodell
(2023-09-29)This thesis evaluates the histopathological effects of a long-term application of Cannabidiol and delta-Tetrahydrocannabiol in a mouse model of the sporadic Alzheimer`s disease in a preventive and therapeutic approach ... -
Der Einfluss von Cannabidiol auf die Alzheimer Pathologie im 5xFAD Mausmodell in einem präventiven Behandlungsansatz
(2023-08-22)This work examines the neurohistological effects of chronic treatment with cannabidiol on pathologies typical of Alzheimer's disease in the cortex and hippocampus of the 5xFAD mouse model. These include accumulation of ... -
Quantitative Analysen hippocampaler Interneuronen in zwei transgenen Alzheimer Mausmodellen
(2022-09-20)Characteristic pathologies of Alzheimer's disease are extracellular amyloid plaques, early intracellular Aβ accumulation and marked neuronal loss. The Tg4-42 mouse model expresses the Aβ4-42 peptide, which accumulates ... -
Cannabinoid-basierte Therapie in einem Modell für die sporadische Alzheimer-Erkrankung
(2022-09-14)The endocannabinoid system (ECS) is involved in several metabolic processes of the human body and has among others a neuroprotective and anti-inflammatory effect on the central nervous system. Tetrahydrocannabinol (THC) ... -
Cooperative Action of Neuroligins and Brain-Derived Neurotrophic Factor Mediates Presynaptic Maturation
(2022-09-02)Mutations in genes for postsynaptic cell adhesion molecules called neuroligins – in particular the isoforms neuroligin-1, neuroligin-3, and neuroligin-4 – have been implicated in autism spectrum disorders. In cultured ... -
Der Einfluss rekombinanter Neuroligine auf die neuronale Reifung
(2022-06-21)Neuroligins are a group of postsynaptic adhesion molecules associated with formation, maturation and function of neuronal synapses. Additionally, some isoforms have been connected to autism spectrum disorders. Neuroligin ... -
Therapeutischer Nutzen einer stabilisierten systemischen Redoxbalance im Rett-Syndrom: Bewertung plethysmographischer und elektrophysiologischer Parameter
(2022-03-08)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene. The MECP2 gene encodes MeCP2 (methyl-CpG-binding protein 2), which acts as a transcriptional regulator and can stimulate and ... -
Der Einfluss von Lithium auf die Myelinisierung im peripheren Nervensystem
(2022-01-27)Lithium salts are used in clinical practice for the prophylaxis of bipolar affective disorder and for the treatment of major depression. In addition, there are many experimental approaches for the treatment of cognitive ... -
Der Einfluss von (-)-Δ9-trans- Tetrahydrocannabinol und Cannabidiol auf die Alzheimer-Pathologie im 5XFAD-Mausmodell
(2021-12-06)The aim of the present work was to investigate the therapeutic influence of THC and CBD regarding behavioral changes, amyloid plaque pathology, neuroinflammation and CB1 receptor expression using the common Alzheimer’s ... -
Evaluierung einer oralen Antioxidantien-Therapie in einem Mausmodell für das Rett-Syndrom
(2021-09-06)Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by spontaneous mutations in the X-chromosomal gene MECP2 encoding methyl-CpG binding protein 2 (MeCP2). Affecting almost exclusively females, it causes ... -
Der Einfluss von humanem Wildtyp-Alpha-Synuclein und seinen Mutationen A30P und A53T auf das Neuritenwachstum primärer dopaminerger Mittelhirnneurone der Ratte
(2021-01-11)Parkinson´s disease (PD) is the second most common neurodegenerative disease with increasing prevalence worldwide. Despite extensive research, current treatments of PD remain purely symptomatic while neuroprotective and ... -
Der Einfluss von humanem α-Synuclein-Wildtyp und der Mutanten A30P und A53T auf die Autophagie und den Transport synaptischer Vesikel in primären Mittelhirnneuronen der Ratte
(2020-09-29)Despite the expanding pathological understanding of Parkinson´s disease (PD) the relevant pathomechanisms are still not completely understood. Previous evidence suggests that disturbed cellular proteindegradation (autophagy) ... -
Analyse von zehn synaptischen Proteinen in Ratten-Hirnschnitten mittels STED-Mikroskopie zeigt geringfügige Unterschiede zwischen Hirnarealen in Bezug auf Quantität und Lokalisation
(2020-06-19)The role of the synapse as a central element of neuron function has been discussed widely over the years. Likewise, differences between different neurons regarding their anatomy, function (motor, sensor, association), ...