Browsing Human- und Zahnmedizin by Referee "Ellenrieder, Volker Prof. Dr."
Now showing items 1-12 of 12
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Mechanismen der Tumorsuppression und Resistenzüberwindung einer therapeutischen GSK-3β- Inhibition im Pankreaskarzinom
(2025-02-17)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of human cancer with a five-year survival of only 11%. Recent studies have shown that PDAC results from a successive accumulation of different ... -
Role of FOXM1, GPX1, and CCNB1 in cisplatin resistance in malignant thymomas and thymic carcinomas
(2024-12-02)Cisplatin resistance in malignant thymomas and thymic carcinomas remains a significant challenge, impairing therapeutic efficacy and patient outcomes. This study investigates the roles of Glutathione Peroxidase 1 (GPX1), ... -
Evaluation der Standard Operating Procedure für das Leitsymptom „Abdominelle Schmerzen” in der Klinischen Akut- und Notfallmedizin
(2024-10-11)The leading symptom ‘abdominal pain’ is one of the most common reasons for patient presentation in German emergency departments. It is not only gaining in importance due to its heterogeneity of differential diagnoses and ... -
Die Rolle der Glykogen Synthase Kinase 3β in der Regulation von DNS-Schäden und Chemotherapieresistenz im Pankreaskarzinom
(2024-09-24)Pancreatic carcinoma is one of the most aggressive solid tumour types and is characterized by pronounced molecular heterogeneity. Research is continuing into molecularly definable subgroups that are suitable for targeted, ... -
Die Funktionsanalyse der Caspase-3 und des Yes-associated Proteins in epithelialen Thymusneoplasien
(2023-02-07)Thymic neoplasms are very rare neoplasms in the thymus that arise from the epithelium of the thymus, located in the mediastinum. Little is known about their etiopathogenesis, but they represent the adult tumor entity with ... -
Proteomische Analyse von neuroendokrinen Tumoren des Thymus und der Lunge
(2022-12-12)Neuroendocrine tumours of the thymus are very rare neoplasms. The closest related group of tumours are neuroendocrine tumours of the lung. Both are classified using the same criteria into four subtypes: typical carcinoid, ... -
The role of the ROBO 3 signaling pathway in pancreatic cancer plasticity
(2022-09-06)Pancreatic ductal adenocarcinoma remains one of the most aggressive cancers with a 5-year survival rate below 10 %. Particularly, the clinical outcome of metastatic pancreatic cancer is extremely poor with a dismal 5-year ... -
Überwindung der Chemoresistenz bei malignen Thymomen und Thymuskarzinomen
(2022-07-18)This work focused on four proteins that have been prominent in previous studies of resistance in tumor therapy. FoxM1 and cyclin B1 are cell cycle regulatory proteins that promote the transition into mitosis. FoxM1 induces ... -
Das Wachstums- und Sporulationsverhalten klinischer Clostridioides-difficile-Isolate unter intestinalen Gallensalzkonzentrationen
(2021-11-10)Problem: Clostridioides difficile infections (CDI) have emerged as the leading cause of hospital-acquired diarrhea. The disruption of physiological gut microbiota by consumption of antibiotics is one of the major risk ... -
Comparative Morphologic and Molecular Classification of Neuroendocrine Tumors of the Thymus in Humans
(2021-04-30)Neuroendocrine tumors (NET) of the thymus are rare neoplasms that share many similarities with their pulmonary counterpart. The WHO 2015 classification of thymic and pulmonary NET divides tumors into typical and atypical ... -
One-carbon metabolism in lung cancer
(2020-10-26)One-carbon metabolism (1CM) plays a central role in cell proliferation and an elevated activity is accounted for the progression of several cancer types. Increased 1CM is a known risk factor for lung cancer and the anti-folate ... -
Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysen
(2015-02-06)One aim of this study was to investigate the associations of genetic polymorphisms in the genes involved in gemcitabine pathways and the cinical outcome of patients with pancreatic ductal adenocarcinoma. A nucleoitide ...