Browsing Human- und Zahnmedizin by Referee "Friede, Tim Prof. Dr."
Now showing items 1-20 of 22
-
Exakte Methoden zur Analyse von Changepoints in binomial-verteilten Sequenzen mit verbesserter Power bei kleinen Fallzahlen
(2024-05-03)Several asymptotic and exact methods exist to detect a change in a sequence of independent binomial random variables. Whenever the sample size or the event rate is small, asymptotic methods may suffer from type I error ... -
Systematisches Review und Metaanalyse publizierter Fallberichte zu Multipler Sulfatase Defizienz
(2023-06-23)Multiple Sulfatase Deficiency (MSD, MIM #272200) is an ultra-rare lysosomal storage disorder that results from mutations in the SUMF1 gene, which encodes formylglycine-generating enzyme (FGE). Pathogenic variants in SUMF1 ... -
Identification of biomarker-defined populations in precision medicine
(2023-03-24)The aim of precision medicine is to identify the treatment that provides the best response for a patient. For this purpose, predictive biomarkers play a crucial role. Due to their ability to define subgroups of patients ... -
Methods for Blinded Sample Size Recalculation in Adaptive Enrichment Designs
(2022-12-21)In precision medicine the potential heterogeneity of patient populations becomes more accessible through technical and medical innovations. A population might be heterogeneous and different strata may in turn respond ... -
Blinded Sample Size Re-estimation for Longitudinal Overdispersed Count Data in Randomized Clinical Trials with an Application in Multiple Sclerosis
(2021-02-22)In many clinical experiments, particularly in randomized clinical trials, the sample size required needs to be assessed and justified. For calculating a clinical trial’s sample size, assumptions have to be made regarding ... -
Bayesian methods for borrowing information in clinical drug development
(2020-12-11)Clinical drug development is the process of investigating potential pharmaceutical therapies in clinical trials. The clinical investigation of drugs consists of four phases. The aim is bringing a candidate drug from early ... -
Planung multizentrischer randomisierter klinischer Studien mit kontinuierlichem Endpunkt
(2020-03-31)Multicentre controlled randomized clinical trials are a cornerstone of modern evidence-based medicine. The benefits of collecting data from more than one centre are numerous, including accelerated recruitment and better ... -
Methodologische Aspekte bei Placebo-kontrollierten randomisierten Crossover-Studien zu chronischen Schmerzerkrankungen
(2020-02-17)Abstracts are an established and typically freely available part of medical science original papers. They allow the reader to quickly access the most important study content. Therefore, it is very important that abstracts ... -
Adaptive designs for clinical trials in cardiovascular diseases
(2018-12-07)Cardiovascular diseases are diseases of the heart and blood vessels constituting a major cause of death and disability worldwide. Cardiovascular drug development aims to deliver efficacious drugs to address the public ... -
Gene-Set Meta-Analysis to Discover Molecular-Biological Pathways Associated to Lung Cancer
(2017-06-09)During the last two decades the search for risk factors of many human diseases turned into a new direction, since it got feasible to gauge the human genome. Genome-wide association studies (GWAS) were carried out to identify ... -
Wort oder Unwort? Eine Analyse der Metapher Medizintourismus in der ethischen Debatte
(2017-05-22)The aim of this dissertation was to analyse the usage of the term 'medical tourism' in the ethical professional debate and to examine the normative consequences of its usage in particular. If looked at it from the ... -
Therapie der koronaren Dreigefäßerkrankung im Alter (Patienten älter als 75 Jahre)
(2017-03-24)Background: Chronic ischemic heart disease take the first place in cause of death in Germany. The proportion of patients aged 75 years or older amounts to more than 80 %. Due to their growing part of population the medical ... -
Stellenwert des Opioidantagonisten Naltrexon bei stationär behandelten Borderline-Patienten
(2016-09-23)Introduction: Although 85% of inpatients with Borderline Personality Disorder (BPD) receive psychotropic drug treatment, no drug is approved for this indication so far. A dysregulation of the endogenous opioid system ... -
Vergleich der Wirksamkeit von Psychopharmaka bei Angststörungen
(2016-01-25)Efficacy of pharmacological treatments for anxiety disorders: a meta-analysis This meta-analysis compares the efficacy of pharmacological treatments for the three main anxiety disorders (social phobia, generalized anxiety ... -
Establishment of a clinical algorithm for the diagnosis of P. falciparum malaria in children from an endemic area using a Classification and Regression Tree (CART) model
(2015-01-20)For the year 2009, the World Health Organization (WHO) estimated 225 million cases of malaria worldwide. Fifty-eight percent of all deaths on the African continent due to malaria were children under 5 years of age. As ... -
Gene-Environment Interaction and Extension to Empirical Hierarchical Bayes Models in Genome-Wide Association Studies
(2014-07-24)There are over 100,000 human diseases of which only around 10,000 are known to be monogenic, resulting from modification in a single gene. Many multifactorial diseases, such as cancer and lung cancer in particular, are ... -
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis
(2014-01-21)Recent studies have shown a decrease in annualized relapse rates (ARRs) in placebo groups of randomized controlled trials (RCTs) in relapsing multiple sclerosis (RMS). This dissertation aimed to describe this trend ... -
Überleben nach prähospitalem Kreislaufstillstand
(2013-08-08)Survival after out-of-hospital cardiac arrest (OHCA) A regional outcome analysis between 1998 and 2009 Background: The analyzed period from 01.01.1998 until 31.12.2008 for this study included altogether three guideline ... -
Wertigkeit neuer kardiovaskulärer Biomarker zur Prädiktion kardiovaskulärer Ereignisse und der Mortalität bei Patienten mit akuter zerebraler Ischämie
(2013-06-21)In industrialized nations, cerebral ischemia manifesting as a stroke or TIA is one of the most frequent causes of death and the most important reason for long-term disability and the overall associated overall costs for ... -
Assoziation von Höhe der antipsychotischen Medikation über die Zeit mit Kognition unter Berücksichtigung des Geschlechts
(2012-06-04)Background: Available anti-psychotic drugs failed to show a positive effect on cognitive impairment, a core symptom of schizophrenic patients. Prescribing anti-psychotics is an essential part of patient treatment. Over the ...