Browsing Human- und Zahnmedizin by Referee "Gross, Oliver Prof. Dr."
Now showing items 1-20 of 23
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Retinale Gefäßverschlüsse nach Impfung gegen SARS-CoV-2 - eine multizentrische Erhebung an deutschen Augenzentren
(2025-03-05)Background: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data from patients with central and branch ... -
Verlaufskontrolle einer prospektiven Beobachtungsstudie bezüglich des Therapieerfolges bei Patienten mit Alport Syndrom
(2024-07-26)Alport Syndrome (AS) is the second most common hereditary kidney disorder globally. It is induced by a pathological collagen IV network caused by variants in the COL4A3, COL4A4, and COL4A5 genes, leading to renal dysfunction ... -
Detektion diagnostischer Frühmarker der Nierenfibrose im Urin von Patienten mit Alport-Syndrom mittels proteomischer Methoden
(2024-02-02)Detection of early diagnostic tools of kidney sclerosis in the urine of patients with Alport-Syndrome using proteomic methods. -
Einfluss früher medikamentöser Intervention auf Krankheitsverlauf und Zeitpunkt des Nierenversagens bei Patienten mit Alport-Syndrom mit einer p.(Gly624Asp)-Variante im COL4A5-Gen
(2023-07-13)Background: ACE-inhibitors (ACEis) and AT1-Antagonist (ARBs) have been established as an effective treatment of Alport syndrome (AS). However, it remained unclear at which stage therapy should be initiated. The present ... -
Entwicklung von Nierenfunktion und Nierenschädigung bei Patienten mit Alport-Syndrom in Abhängigkeit des Beginns einer nephroprotektiven Therapie
(2023-03-28)Alport syndrome is a hereditary collagen type IV disease which affects kidneys, eyes and hearing. The extent of kidney involvement is prognostically relevant; if left untreated, terminal kidney failure can occur at an early ... -
Auswirkung von ACE-Hemmern auf die Nierenfunktion bei hereditären Nierenerkrankungen wie dem Alport-Syndrom im Mausmodell
(2022-04-22)Alport syndrome is a hereditary kidney disease that leads to the development of progressive kidney failure. It is based on mutations in the COL4 genes. Homozygous or hemizygous patients develop the disease earlier and more ... -
Einfluss der Haptoglobinkonzentration auf die Inzidenz akuter Nierenschädigung und Validierung eines Frühmarkers der akuten Nierenschädigung nach kardiochirurgischen Operationen
(2022-03-22)Acute Kidney Injury (AKI) is a complex and multifactorial induced syndrome leading to increased morbidity and mortality. It is frequently seen after cardiac surgery with cardiopulmonary bypass. One major risk factor for ... -
Einfluss von salzreicher Ernährung auf die hyperperfundierte Niere nach Uninephrektomie bei hereditären Nierenerkrankungen wie dem Alport-Syndrom im Mausmodell
(2021-08-12)The filtration function of the kidney in the glomerulum consists of the endothelial cell, basement membrane (GBM) and podocyte. Collagen IV is, among other things, a major component of GBM. Homozygous mutations in type IV ... -
Der langfristige Effekt einer RAAS-Blockade auf den Krankheitsverlauf bei heterozygoten Mutationsträgern des Alport-Syndroms
(2020-02-11)Alport Syndrome (AS) is a hereditary disease that leads to a progressive loss of glomerular basement membrane function due to mutations in collagen IV, but AS is also associated with extra renal symptoms such as hearing ... -
Prospektive Verlaufsstudie über die Auswirkung der RAAS-Blockade bei Trägern des Alport-Syndroms
(2018-07-05)The aim of the present study was the prospective follow-up of Alport patients with regard to disease progression. A main focus was on the consideration of the different therapy groups, which were divided after the start ... -
Untersuchung der Transportvorgänge des Prolyl-Hydroxylase-Hemmers ICA an den Transportern OAT1, OAT2, OAT3 und OAT4 von proximalen Nierentubuluszellen
(2017-10-27)This thesis discusses the interactions between ICA and the organic anion transporters OAT1, OAT2, OAT3 and OAT4. ICA is a substance which can inhibit the prolyl hydroxylase domain. This leads to an upregulation of hypoxia ... -
Nidogen-2 in der Pathogenese Kollagen IV-assoziierter Nephropathien bei zusätzlicher Podocin-Mutation
(2016-11-21)Collagen IV-related nephropathies are hereditary diseases affecting the glomerular basement membrane. Homozygous aberrations of COL4A3 or COL4A4 gene or X-linked mutations of COL4A5 gene are responsible for Alport syndrome ... -
Veränderung der Nierenfunktion, des Proteoms und des Phosphorylierungsstatus der Proteine bei Alport-Mäusen unter Mycophenolat-Mofetil
(2016-10-27)Objectives: We aimed to investigate the effects of mycophenolate mofetil (MMF) on kidney function, the proteom and protein phosphorylation in a mouse model for the human Alport syndrome. Methods: COL4A3-deficient (COL4A3-/-) ... -
Regulation des Sulfat-Anionen-Transporters-1, sat-1, in Caco2-Zellen durch Oxalat und dessen Vorstufen
(2014-11-25)Nephrolithiasis is a major health problem caused by hyperoxaluria. The sulfate anion transporter-1 which transports sulfate and oxalate might be involved in the development of hyperoxaluria, so further information concerning ... -
Der Einfluss des DDR1+/-/NPHS2+/R140Q-Genotyps auf die Interaktion zwischen glomerulärer Basalmembran und Schlitzmembran im Tiermodell
(2014-05-09)Heterozygous Alport mutations of type IV collagen genes lead to Benign Familial Hematuria without excessive proteinruia or progression to end stage kidney disease. Heterozygous polymorphisms of the podocin-gene also do not ... -
Einfluss der Kollagenrezeptoren ITGA2 und DDR1 in der Pathogenese von glomerulären Nierenerkrankungen am Doppelknockout-Tiermodell
(2014-05-07)The majority of chronic renal diseases is caused by glomerular defects. In this dissertation therefore the role of collagen – receptors DDR1 and ITGA 2 in the pathogenesis of glomerular defects was investigated. The main ... -
Evaluierung, Validierung und Anwendung eines Scores zur Stratifizierung des Risikos akuter Nierenfunktionsstörungen
(2014-04-17)Postoperative acute kidney injury (AKI) is a frequently observed phenomenon after cardiac surgery with the use of cardio-pulmonary-bypass (CPB) and a severe complication which is associated with adverse patient outcome. ... -
Bestimmung von Prognosemarkern unter nephroprotektiver Therapie mit ACE-Hemmern bei chronischer Nierenfibrose am Beispiel des Alport-Syndroms
(2013-11-26)Firstly described in 1927, Alport syndrome is a progressive hereditary nephropathy. Untreated, it leads to end-stage renal failure and is associated with the symptoms of hematuria and proteinuria. The aim of this work was ... -
Präemptive Therapie mit Angiotensin-Converting-Enzyme-Inhibitoren verzögert Nierenersatztherapie bei heterozygoten Mutationsträgerinnen mit X-chromosomalem und autosomal-rezessivem Alport-Syndrom
(2013-02-08)The Alport syndrome (AS) is a hereditary chronic kidney disease which is characterized by ultrastructural lesions of the glomerular basement membrane (GBM), hearing loss and ocular changes. The cause of AS are various ... -
Restless-Legs-Syndrom bei dialysepflichtiger Niereninsuffizienz: Untersuchungen zur Pathophysiologie und Schlafqualität – spielt Homocystein eine Rolle?
(2012-06-19)Sleep disturbances are a common problem among patients with chronic renal insufficiency on hemodialysis and often have multiple causes. One is the high prevalence of the uremic form of restless legs syndrome (RLS). Associated ...