Browsing Human- und Zahnmedizin by Referee "Kehlenbach, Ralph Prof. Dr."
Now showing items 1-8 of 8
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Effects of overexpression of the ALS associated protein TDP-43 and its mutant on the axonal and somal proteome in compartimentalized primary cortical neurons of rats
(2024-08-22)Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor nervous system. During its course, the function of the upper and lower motor neurons is predominantly lost. It is a very severe ... -
Bestimmung der mitochondrialen Atmungskettenfunktion im Rett-Syndrom mittels hochauflösender Respirometrie
(2023-06-05)Rett syndrome is a disorder frequently caused by pathological changes in the MECP2 gene, an essential transcription factor. It results in various morphological and biochemical alterations in mitochondria, which affect a ... -
Kombinatorische Analyse von Nanobody-markierten Epitopen zur Proteinbestimmung
(2021-02-05)The ability to identify and measure proteins is important in biological and medical research. It enables insights into the subcellular organizations and functions that rely on the collaboration and organization of thousands ... -
Die Zielsteuerung peroxisomaler Membranproteine mit tail anchor
(2017-11-15)The targeting of PEX26, a peroxin involved in peroxisome biogenesis and maintenance, is similar to Pex15- its analog in baker's yeast. Both are tail anchored proteins, that share more than a common protein class and function: ... -
Einfluss des Prolyl-4-Hydroxylase-Domäne 2-Enzyms auf die Migration der myeloischen Zelllinien RAW und J774
(2017-04-11)HIF-1 is an essential transcription factor for macrophage function, as it usually takes place in hypoxic tissues. It's alpha-subunit is marked oxyxen-dependendly for proteasomal degradation, leading to hypoxic HIF-1alpha ... -
Peroxisomale Biogenese - Beteiligung Dynamin-ähnlicher Proteine und die Rolle des endoplasmatischen Retikulums
(2016-09-19)This present work deals with the peroxisomal biogenesis and should help to understand it. The work focuses on the participation of the dynamin-like protein Vps1p in the process of the peroxisomal biogenesis in S. ... -
Einfluss des extrazellulären pH-Werts auf den Transport von para-Aminohippurat über den organischen Anionentransporter 1
(2015-02-10)Organic anion transporter 1 (OAT1) is one of the transporters responsible for renal elimination of organic anions. In the present study, the influence of extracellular pH on the transport-activity of OAT1 was examined using ... -
Functional Assessment of Biomarkers in Gemcitabine-Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1
(2013-10-31)Pancreatic ductal adenocarcinomas are the fourth leading cause of death among all kinds of cancers. The poor prognosis is due to usually late diagnosis and, in most cases, the available therapeutic options lack sustained ...