Browsing Human- und Zahnmedizin by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 1-7 of 7
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Age-dependent alterations of medial olivocochlear efferent synapses in the murine cochlea
(2024-10-11)Age-related hearing loss, also referred to as presbycusis, is defined as bilateral, symmetrical sensorineural hearing loss caused by age-related alterations of the auditory system. Previous studies on ARHL have investigated ... -
Exercise-induced microRNA modulations and their role in cognition
(2022-09-27)The number of people suffering from dementia is constantly increasing leading to massive long-term economic and social consequences. A healthy lifestyle and physical exercise in particular are well known for their positive ... -
Oligodendrozytenpopulationen in Läsionen der multiplen Sklerose sowie der toxisch- und autoimmun-induzierten Demyelinisierung
(2021-07-21)The objective of the present work was to investigate the density of cells of the oligodendroglial lineage in early lesions of MS patients as well as in animal-derived tissue samples. Demyelination was studied within the ... -
Nanobody-basierter Sensor für die Zell-zu-Zell-Übertragung von α-Synuclein bei Morbus Parkinson
(2021-05-18)Aggregation and cell-to-cell transmission of α-Synuclein (αSyn) are hallmarks of several neurodegenerative diseases, including Parkinson's disease. In this work, it is shown that the nanobody NbSyn87, previously described ... -
Effects of the microRNA cluster 132/212 in primary dopaminergic neurons
(2021-02-19)The microRNA (miRNA) cluster 132/212 is highly involved in the regulation of cell growth and maturation in neurons and other cell types. This work investigated effects of increased levels of the miRNA strands miR-132-3p ... -
Dreidimensionale Analyse von Synapsen in hippocampalen Zellkulturen
(2020-06-18)The following work focuses on a three - dimensional analysis and reconstruction of synapses. The central nervous system contains approximately 100 billion neurons, with about 1.000 synapses per neuron. Synapses serve as a ... -
Neuropathological and behavioral alterations in two transgenic mouse models of Alzheimer´s disease
(2016-07-05)According to the influential amyloid cascade hypothesis cerebral accumulation of Aβ is the key event in the pathogenesis of Alzheimer´s disease. Aβ deposits occur as soluble forms, as well as insoluble forms. It is assumed ...