Browsing Human- und Zahnmedizin by Referee "Rizzoli, Silvio O. Prof. Dr."
Now showing items 1-12 of 12
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Optogenetic characterization of targeting-optimized Chronos and f-Chrimson variants for auditory encoding in mice
(2024-12-03)Electrical cochlear implants bypass the physiological micromechanics and synaptic sound encoding by sensory hair cells in the cochlea and provide state-of-the-art treatment of sensorineural hearing loss. To overcome the ... -
Investigation on female and male hippocampal neurons
(2024-11-12)There is no doubt that there are differences between the sexes. According to present knowledge, they start with the question of whether an individual inherits a second X chromosome or a Y chromosome. From this point ... -
A novel tool for neuronal physiology and pathology: optimization of secondary ion mass spectrometry approaches
(2023-10-05)Secondary Ion Mass Spectrometry (SIMS) is a powerful tool for characterizing the chemical composition of solid samples and thin films, offering high sensitivity and spatial resolution. While initially developed for geology, ... -
Nanoskalauntersuchungen vom zellulären Metabolismus mittels Sekundärionen-Massenspektrometrie
(2022-11-15)Alzheimer is the most neurodegenerative disease. Hallmark of Alzheimer’s disease ist he pathological accumulation of the proteins Aβ and Tau. The aggregates of these accumulation are called Aβ-plaques and neurofibrillary ... -
Hörphysiologische Charakterisierung zweier Mausmodelle mit Schwerhörigkeit
(2021-11-11)In this work, two transgenic mouse models were characterized that showed disruption either of presynaptic Ca2+-influx (CaVβ2) in inner hair cells or of the cochlear K+-cycle (Cx26) by targeted mutagenesis. Approaches of ... -
Projektionsmuster GABAerger Neurone auf Dendriten von Martinotti-Zellen im somatosensorischen Kortex
(2021-11-03)Cortical processing of information is significantly influenced by inhibitory GABAergic Interneurons, although they only account for about 15-20% of all cortical neurons. Three main subpopulations can be distinguished based ... -
Nanobody-basierter Sensor für die Zell-zu-Zell-Übertragung von α-Synuclein bei Morbus Parkinson
(2021-05-18)Aggregation and cell-to-cell transmission of α-Synuclein (αSyn) are hallmarks of several neurodegenerative diseases, including Parkinson's disease. In this work, it is shown that the nanobody NbSyn87, previously described ... -
Kombinatorische Analyse von Nanobody-markierten Epitopen zur Proteinbestimmung
(2021-02-05)The ability to identify and measure proteins is important in biological and medical research. It enables insights into the subcellular organizations and functions that rely on the collaboration and organization of thousands ... -
Multiplexe optische und Rasterkraftmikroskopie für biomedizinische Bildgebung
(2020-07-03)Function or malfunction of an organism highly depend on the variety of its expressed proteins, the so-called Proteom. Science and clinical medicine have become increasingly interested in methods which precisely detect not ... -
Analyse von zehn synaptischen Proteinen in Ratten-Hirnschnitten mittels STED-Mikroskopie zeigt geringfügige Unterschiede zwischen Hirnarealen in Bezug auf Quantität und Lokalisation
(2020-06-19)The role of the synapse as a central element of neuron function has been discussed widely over the years. Likewise, differences between different neurons regarding their anatomy, function (motor, sensor, association), ... -
Dreidimensionale Analyse von Synapsen in hippocampalen Zellkulturen
(2020-06-18)The following work focuses on a three - dimensional analysis and reconstruction of synapses. The central nervous system contains approximately 100 billion neurons, with about 1.000 synapses per neuron. Synapses serve as a ... -
Quantitative Anatomie zweier Formen von dendritischen Dornfortsätzen an hippocampalen Pyramidenzellen
(2019-02-22)This study deals with the anatomy of the postsynaptic spines from hippocampal pyramidal cells. Mushroom spines as well as stumpy spines are analyzed. While the anatomy and function of the presynapse is well-researched, the ...