Dokumente Human- und Zahnmedizin nach Gutachter "Stadelmann-Nessler, Christine Prof. Dr."
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Charakterisierung von BCAS1-positiven Oligodendrozyten während der menschlichen Gehirnentwicklung
(2024-02-05)This work investigated the comparison between different stages of pre- and early postnatal development of oligodendrocytes in the white matter of the central nervous system. The main focus was to aim at BCAS1+ oligodendrocytes ... -
Expressionsmuster von EBV mikroRNAs in Hodgkin Lymphomen
(2023-03-24)Epstein-Barr virus encodes 40 different miRNAs with considerable impact on cellular functions of the latently infected cell. In this study EBV miRNA expression patterns in EBV-positive Hodgkin lymphoma and other malignant ... -
Neuron-Glia Crosstalk: Investigating Immune-Cell Modulation in the CNP1 Null Mutant Mouse
(2023-03-01)Myelin sheaths built by oligodendrocytes in the central nervous system (CNS) are not only important insulators that enable the fast saltatory propagation of action potentials but also fulfill metabolic support functions ... -
Passive Immunisierung mit dem monoklonalen Antikörper NT4X am Tg4-42-Mausmodell für die sporadische Form der Alzheimer Erkrankung
(2023-01-27)Alzheimer´s dementia is a chronic-progressive neurodegenerative disease that can lead to extensive impairments in the daily life of affected patients due to pronounced cognitive impairments. Significant neuropathological ... -
Regulation des Autophagieproteins ULK1 im MPTP-Mausmodell des Morbus Parkinson
(2022-11-08)Parkinson’s disease (PD) is a widespread neurodegenerative condition. Owing to the absence of suitable biomarkers, a diagnosis can only be made upon onset of clinical symptoms like tremor, rigidity or bradykinesia. They ... -
Effekte einer pharmakologischen Inhibition der ULK1-Kinase auf die akute axonalen Degeneration in vivo
(2022-09-05)Background: Axonal degeneration is a key and early pathological feature in neurodegenerative and traumatic disorders of the central nervous system. A focal lesion to an axon is followed by a rapid disintegration within ... -
Charakterisierung der Oligodendroglia in akuten und chronischen Entmarkungsläsionen der Maus
(2022-09-05)MS is a chronic inflammatory autoimmune disease of the CNS of unknown etiology associated with demyelinating lesions. In addition to chronic demyelinated lesions, there are also remyelinated areas in the CNS. Therapeutically, ... -
Spreading Depression induzierte Redoxveränderungen in hippokampalen Neuronen der Maus
(2022-08-03)Spreading depression (SD) is a neurological phenomenon characterized by massive neuronal and glial depolarization that slowly spreads in brain tissue at rates of several millimeters per minute. Due to the almost complete ... -
Histologische Veränderungen von primären ZNS-Lymphomen nach Steroidtherapie im Vergleich zu chronisch-entzündlichen ZNS-Erkrankungen
(2022-04-22)Primary central nervous system lymphomas (PCNSL) can resemble multiple sclerosis (MS) lesions not only clinically and radiologically, but also histologically if they have been pre-treated by glucocorticoids. They then ... -
Tränenflüssigkeit als mögliche Quelle für Biomarker bei Patienten mit einem idiopathischem Parkinson-Syndrom
(2022-03-21)Idiopathic Parkinson's disease is the second most common neurodegenerative disorder worldwide with a growing prevalence in the continuously aging population. Until today, the diagnosis of Parkinson's disease is mainly based ... -
Zeitverlauf und Therapie axonaler Schädigung bei NMO
(2021-10-25)In this doctoral thesis, the time course of axonal damage and the effect of glutamatergic and purinergic receptor antagonists on acute axon pathology were investigated in the focal experimental NMO rat model for the first ... -
Einfluss der sauren und der neutralen Sphingomyelinasen auf Produktion und Zusammensetzung extrazellulärer Vesikel von Mamma-Karzinom-Zelllinien
(2021-07-06)Extracellular vesicles, including microvesicles and exosomes, are important mediators in cell-cell-communication, both in physiological and pathological processes. Due to their diagnostic and therapeutic potential they ... -
Ergebnisse paläopathologischer Untersuchungen zu meningealen Reaktionen an Kinderskeleten präkolumbischer Populationen aus dem südöstlichen Nordamerika (USA), dem zentralmexikanischen Hochland und dem östlichen Tiefland Yucatáns (Mexiko)
(2019-08-22)The health status of a prehistoric population can be determined by palaeopathological investigation. The rate of childhood illness correlates with the prevailing living conditions. In this research the type, frequency ... -
Der Einfluss von Interleukin-3 auf die Läsionslast der experimentellen autoimmunen Enzephalomyelitis
(2018-06-01)Multiple sclerosis is an inflammatory disease of the central nervous system. Despite decades of research its etiology remains unclear. Keeping in mind that experimental autoimmune encephalomyelitis is an artificially induced ... -
Analyse neurodegenerativer Prozesse im Gyrus Dentatus im Tg4-42-Mausmodell der Alzheimerdemenz
(2018-03-27)Alzheimer's disease is a neurodegenerative disease and the most common form of dementia. Hyperphosphorylated tau and extracellular Aβ deposits are classical neuropathological hallmarks of AD. In addition to extracellular, ... -
C-terminally truncated Amyloid-β peptides in Alzheimer’s dementia: Deposition of Aβ37, Aβ38, and Aβ39 in the brains of patients with sporadic and familiar Alzheimer’s dementia and in transgenic mouse models.
(2018-01-24)Alzheimer's dementia is a devastating neurodegenerative disease characterized by profound neuropathological changes of the brain. Imbalances in the production of aggregation-prone Amyloid-Beta Peptides are believed to play ... -
Skorbutnachweis an frühmittelalterlichen und frühneuzeitlichen archäologischen Skeletfunden unter Anwendung eines kombinierten makroskopischen und lichtmikroskopischen Untersuchungsverfahrens
(2017-10-09)This thesis describes the examination of 143 archaeological slecetal findings from early medieval age and early modern ageto find traces of scurvey.
Vitamin C deficiency leads to poor collagen synthesis. Therefore ... -
Immunhistochemische Untersuchung von Oligodendrozyten im post- mortem Hippokampus bei Schizophrenie
(2017-05-18)The prevalence of schizophrenia is about 1%, and the disease is also one of the most common causes of life-threatening diseases due to the age of the disease in young adulthood and frequent social disability. In the ... -
Liquormarker in der Diagnostik bei Patienten mit Morbus Parkinson, Parkinson-Demenz-Komplex und Morbus Alzheimer
(2015-09-24)Suffering from dementia, such as Alzheimer’s disease ("AD") and Parkinson’s disease with dementia ("PDD"), has far-reaching consequences for the patient’s self-determined life. In contrast to Alzheimer’s disease, there’s ... -
Auswirkung einer selektiven p75-Neurotrophinrezeptor-Defizienz im Immun- oder Zentralnervensystem auf die experimentelle autoimmune Enzephalomyelitis
(2015-01-29)The clinical manifestation of multiple sclerosis (MS) is largely due to axonal damage and axonal loss caused by inflammation and demyelination. As an explanation for the different extents of axonal damage and thus the ...