Browsing Human- und Zahnmedizin by Referee "Voigt, Niels Prof. Dr."
Now showing items 1-6 of 6
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Kalziumhandling und Kalziumpufferung bei familiärer dilatativer Kardiomyopathie am Modell der induzierten pluripotenten Stammzellen
(2024-01-29)Dilated cardiomyopathy (DCM) is a heterogeneous disease characterised by left ventricular dilatation and a reduced ejection fraction. In addition to progressive left heart failure, the poor clinical prognosis is primarily ... -
Postoperatives Vorhofflimmern – eine klinische und experimentelle Risikoanalyse
(2023-05-24)Postoperative atrial fibrillation (poAF) is one of the most common complications after cardiac surgery and is associated with increased mortality and morbidity for the patients affected. Since the interplay of clinical and ... -
Zelluläre Elektrophysiologie und Calciumhomöostase an Kardiomyozyten aus induzierten pluripotenten Stammzellen von einem Patienten mit Fallot'scher Tetralogie
(2021-08-26)Introduction: Tetralogy of Fallot (TOF) is the most common congenital cyanotic heart defect and many patients with TOF proceed to suffer from arrhythmias (both atrial and ventricular). The aim of this thesis was to identify ... -
Nanodomain clustering mechanisms of Junctophilin-2 in human kidney, cardiac and skeletal muscle cells
(2020-09-07)Junctophilin-2 (JPH2) –a tail-anchored protein located in the sarcoplasmic reticulum (SR) membrane– is known to stabilise Calcium Release Units (CRUs) in the ~12 nm wide junction between the sarcolemma (SL) and the SR. ... -
Die Rolle der Serin/Threonin-Phosphatasen bei der Dysregulation des Calcium-Stoffwechsels in der menschlichen Herzerkrankung
(2019-01-04)Disruption of Ca2+-homeostasis is a key pathomechanism in the development of heart failure by compromising EC-coupling. While the role of respective kinases has been extensively studied during the last decades, the ... -
Über die differentielle Regulation von Ionenkanälen in spezifischen Nanodomänen atrialer und ventrikulärer Kardiomyozyten
(2017-05-19)Atrial cardiomyocytes express a transverse-axial tubule system, which is mainly composed of voluminous axial tubule (AT) components. Upon membrane depolarisation L-type calcium channels (Cav1.2) localised to AT sites ...